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DOI: 10.1055/s-0034-1382561
New dammarane-type triterpenes from antiosteoporotic hexanes extract of Cissus quadrangularis L.
Cissus quadrangularis L. (CQ), a native plant of Southeast Asia in the Vitaceae family, were used in Indian traditional medicine for healing bone fractures. From our previous data, the CQ hexanes extract possessed antiosteoporotic effect in an ovariectomized mice model. Although a number of studies have mentioned the isolation of chemical constituents from an ethanolic extract of CQ, there is no report on the compounds identified from its hexanes extract. Herein, the CQ hexanes extract was investigated for identification of the compounds and five dammarane-type triterpenes were isolated for the first time even from the Vitaceae family. Four of them were found to be new including 1 esterified with palmitic acid. Their structures were determined by NMR and MS spectroscopic data.