Planta Med 2014; 80 - PD140
DOI: 10.1055/s-0034-1382561

New dammarane-type triterpenes from antiosteoporotic hexanes extract of Cissus quadrangularis L.

T Pathomwichaiwat 1, 3, Z Ali 1, N Abe 1, IA Khan 1, 2, P Ochareon 4, S Prathanturarug 3
  • 1National Center for Natural Products Research
  • 2Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677
  • 3Department of Pharmaceutical Botany, Faculty of Pharmacy
  • 4Department of Anatomy, Faculty of Dentistry, Mahidol University, Bangkok 10400, Thailand

Cissus quadrangularis L. (CQ), a native plant of Southeast Asia in the Vitaceae family, were used in Indian traditional medicine for healing bone fractures. From our previous data, the CQ hexanes extract possessed antiosteoporotic effect in an ovariectomized mice model. Although a number of studies have mentioned the isolation of chemical constituents from an ethanolic extract of CQ, there is no report on the compounds identified from its hexanes extract. Herein, the CQ hexanes extract was investigated for identification of the compounds and five dammarane-type triterpenes were isolated for the first time even from the Vitaceae family. Four of them were found to be new including 1 esterified with palmitic acid. Their structures were determined by NMR and MS spectroscopic data.

Fig. 1