New cytotoxic guaianolides from Centaurea aegyptiaca

KY Orabi; HG Sary

doi:10.1055/s-0034-1382517

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Planta Med 2014; 80 - PD96
DOI: 10.1055/s-0034-1382517

New cytotoxic guaianolides from Centaurea aegyptiaca

KY Orabi ¹, HG Sary ¹

¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Kuwait

Congress Abstract

Chromatographic purification of the ethanol extract of Centaurea aegyptiaca (Family Asteraceae) aerial parts afforded two new bioactive guaianolide sesquiterpene lactones, named cenegyptin A (15-methoxy cebellin J, 1) and cenegyptin B (2). The cytotoxicity (IC₅₀, µM) of the two compounds were evaluated against liver (HEPG2) and larynx (HEP2) carcinoma cell lines in comparison to the normal fibroblasts (BHK). Doxorubicin was used as a positive control. Compound 1, the most potent of both, showed cytotoxic activity against HEPG2 and HEP2 with IC₅₀ values of 7.16 and 7.51, respectively. However, compound 2 exhibited a weaker activity on both cell lines (IC₅₀= 24.24 with HEPG2, and 32.40 with HEP2).