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Planta Med 2014; 80 - PD61
DOI: 10.1055/s-0034-1382482
DOI: 10.1055/s-0034-1382482
New bioactive lupane triterpene coumaroyl esters isolated from Buxus cochinchinensis
Five new lupane triterpene coumaroyl esters (1 – 5) were isolated from a CHCl3-soluble partition of a methanol extract of Buxus cochinchinensis Pierre ex Gagnep. (Buxaceae) collected in South Vietnam. Isolation work was monitored using human colon cancer cells (HT-29). The structures of the new compounds (1 – 5) were determined on the basis of spectroscopic data interpretation. In addition to the cytotoxicities against HT-29 cells and NF-κB (p65) inhibitory activities in an ELISA assay, all isolates were also evaluated for their in vitro antimalarial and antifungal activities.