Planta Med 2014; 80 - PD61
DOI: 10.1055/s-0034-1382482

New bioactive lupane triterpene coumaroyl esters isolated from Buxus cochinchinensis

L Pan 1, U Muñoz Acuña 2, H Chai 1, TN Ninh 3, HLR Rakotondraibe 1, EJ Carcache de Blanco 1, 2, DD Soejarto 4, 5, AD Kinghorn 1
  • 1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy
  • 2Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
  • 3Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
  • 4Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
  • 5Department of Botany, Field Museum of Natural History, 1400 S. Lake Shore Drive, Chicago, IL 60605, USA

Five new lupane triterpene coumaroyl esters (1 – 5) were isolated from a CHCl3-soluble partition of a methanol extract of Buxus cochinchinensis Pierre ex Gagnep. (Buxaceae) collected in South Vietnam. Isolation work was monitored using human colon cancer cells (HT-29). The structures of the new compounds (1 – 5) were determined on the basis of spectroscopic data interpretation. In addition to the cytotoxicities against HT-29 cells and NF-κB (p65) inhibitory activities in an ELISA assay, all isolates were also evaluated for their in vitro antimalarial and antifungal activities.