Planta Med 2014; 80 - PD59
DOI: 10.1055/s-0034-1382480

Bioactive indole alkaloids isolated from Alstonia angustifolia

L Pan 1, C Terrazas 2, U Muñoz Acuña 3, TN Ninh 4, H Chai 1, EJ Carcache de Blanco 1, 3, DD Soejarto 5, 6, AR Satoskar 2, AD Kinghorn 1
  • 1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy
  • 2Department of Pathology, College of Medicine
  • 3Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, OH 43210, USA
  • 4Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
  • 5Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
  • 6Department of Botany, Field Museum of Natural History, 1400 S. Lake Shore Drive, Chicago, IL 60605, USA

A new sarpagine-type indole alkaloid (1), together with nine known alkaloids (2 – 9), were isolated from the stems of Alstonia angustifolia Wall. ex A. DC. (Apocynaceae) collected in South Vietnam. Compounds 1 – 10 were evaluated for their NF-κB (p65) inhibitory activities against HT-29 cells in an ELISA assay. The new sarpagine alkaloid (1), was found to show significant NF-κB inhibitory activity (ED50= 1.2 µM). Furthermore, all the isolates (1 – 10) were tested in vitro for their antileishmanial activity, and compounds (1 – 4, 6, 8 – 10) were found to show leishmaniacidal activities.