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Planta Med 2014; 80 - PD59
DOI: 10.1055/s-0034-1382480
DOI: 10.1055/s-0034-1382480
Bioactive indole alkaloids isolated from Alstonia angustifolia
A new sarpagine-type indole alkaloid (1), together with nine known alkaloids (2 – 9), were isolated from the stems of Alstonia angustifolia Wall. ex A. DC. (Apocynaceae) collected in South Vietnam. Compounds 1 – 10 were evaluated for their NF-κB (p65) inhibitory activities against HT-29 cells in an ELISA assay. The new sarpagine alkaloid (1), was found to show significant NF-κB inhibitory activity (ED50= 1.2 µM). Furthermore, all the isolates (1 – 10) were tested in vitro for their antileishmanial activity, and compounds (1 – 4, 6, 8 – 10) were found to show leishmaniacidal activities.