Planta Med 2014; 80 - PD39
DOI: 10.1055/s-0034-1382460

Three new triterpenoid glycosides and a new secoiridoid glycoside from the aerial part of Weigela subsessilis

YM Won 1, 2, ZK Seong 1, 2, JL Kim 1, 2, HH Song 3, DY Kim 3, JH Kim 3, SR Oh 1, 3, HW Cho 4, JH Cho 4, HK Lee 1, 2
  • 1Biomolecular Science, Korea University of Science and Technology, Daejeon 305 – 806, Korea
  • 2Targeted Medicine Research Center, Korea Research Institute of Bioscience & Biotechnology, yeongudanji-ro 30, Yangcheong-ri, Ochang-eup, Cheongwon-gun, Chungbuk 363 – 883, Korea
  • 3Natural Medicine Research Center, KRIBB, Chungbuk 363 – 883, Korea
  • 4Joennam Development Institute for Korean Traditional Medicines, 288 Woodland-gil Anyang-myeon Jangheung-Gun, Jeonnam, Korea

The plant Weigela subsessilis L. H. BAILEY is an endemic species that grows over all in Korea. It showed anti-complementary activity, inhibitory effect of LDL oxidation, and stimulation of glucose uptake effect. However, few investigations have been reported about this plant. Therefore, to find more constituents of this plant, we isolated three new triterpenoid glycosides, loniceroside K-M (1 – 3), and a new secoiridoid glycoside, picrogentioside D (4), along with 11 known compounds from our phytochemical investigation of the methanolic extract of the aerial part from W. subsessilis. Among the 11 known compounds, five compounds (5, 8, 13 – 15) have not been reported in Weigela yet. It is the first time we report these compounds in Weigela Their structure were tentatively identified by comparison with reference compounds, extensive spectroscopic analysis, including two-dimensional (2D)-NMR experiments and ESIMS data.