The Effect of Pistacia atlantica Var. mutica Mouthwash on Dental Plaque Bacteria and Subgingival Microorganisms: a Randomized and Controlled Triple-blind Study

S. Arami; M. A. Mojaddadi; R. Pourabbas; M. T. Chitsaz; A. Delazar; H. Mobayen

doi:10.1055/s-0034-1382051

Drug Research, Table of Contents

Drug Res (Stuttg) 2015; 65(09): 463-467
DOI: 10.1055/s-0034-1382051

Original Article

The Effect of Pistacia atlantica Var. mutica Mouthwash on Dental Plaque Bacteria and Subgingival Microorganisms: a Randomized and Controlled Triple-blind Study

S. Arami

¹Department of Periodontics, Faculty of Dentistry & Dental and Periodontal research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

M. A. Mojaddadi

¹Department of Periodontics, Faculty of Dentistry & Dental and Periodontal research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

R. Pourabbas

¹Department of Periodontics, Faculty of Dentistry & Dental and Periodontal research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

M. T. Chitsaz

¹Department of Periodontics, Faculty of Dentistry & Dental and Periodontal research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

A. Delazar

²Department of Pharmacognosy, Faculty of Pharmacy & Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

,

H. Mobayen

³Department of Microbiology, Faculty of Medicine, Islamic Azad University, Tabriz branch, Tabriz, Iran

› Author Affiliations

Abstract

Dental plaque is a well-documented etiologic factor for periodontal diseases. While chlorhexidine (CHX) is the gold-standard agent for treating dental plaques, undesirable side effects are often found after continuous use of the mouthwash. Therefore, this single-center, randomized, triple-blinded and clinical trial was undertaken to evaluate the efficacy of Pistacia atlantica Var. mutica extract mouthwash on de novo dental plaque bacteria and subgingival microorganisms compared to CHX on a total of 28 patients. The mean aerobic plaque bacterial count of patients at baseline was 2.17×10⁶. After 4 days of treatment, there were statistically significant decreases in the mean aerobic bacteria in the patients who received P. atlantica and/or CHX (7.25×10⁴, p=0.006) and (9.91×10³, p=0.002), respectively, compared to the patients who received the placebo (6.26×10⁵). This study showed that P. atlantica mouthwash is effective against gingival microorganisms. Because of its reduced side effects, P. atlantica mouthwash may be a good alternative choice for patients.

Key words

pistacia atlantica - mouthwash - dental plaque bacteria - subgingival microorganisms - chlorhexidine

Full Text

References

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