Synthesis 2015; 47(18): 2826-2830
DOI: 10.1055/s-0034-1381053
special topic
© Georg Thieme Verlag Stuttgart · New York

Synthesis of a Cholesterol Side-Chain Triazole Analogue via ‘Click’ Chemistry

Insa Seck
a  Département de Chimie, Faculté de Medecine, de Pharmacie et d’Odonto-stomatologie, Université Cheikh Anta Diop, Dakar, Sénégal   Email: matarsec@yahoo.fr
,
Alioune Fall
b  Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal
,
Carmen Lago
c  Departamento de Química Orgánica, Facultad de Química y Instituto de Investigación Biomedica (IBI), Universidade de Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain   Email: yagamare@uvigo.es
,
Massène Sène
b  Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal
,
Mohamed Gaye
b  Laboratoire de Chimie de Coordination Organique (LCCO), Département de Chimie, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal
,
Matar Seck*
a  Département de Chimie, Faculté de Medecine, de Pharmacie et d’Odonto-stomatologie, Université Cheikh Anta Diop, Dakar, Sénégal   Email: matarsec@yahoo.fr
,
Generosa Gómez
c  Departamento de Química Orgánica, Facultad de Química y Instituto de Investigación Biomedica (IBI), Universidade de Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain   Email: yagamare@uvigo.es
,
Yagamare Fall*
c  Departamento de Química Orgánica, Facultad de Química y Instituto de Investigación Biomedica (IBI), Universidade de Vigo, Campus Lagoas de Marcosende, 36310 Vigo, Spain   Email: yagamare@uvigo.es
› Author Affiliations
Further Information

Publication History

Received: 30 April 2015

Accepted after revision: 29 June 2015

Publication Date:
03 August 2015 (online)

Abstract

An efficient preparation of a cholesterol analogue possessing a triazole ring is achieved starting from commercially available stigmasterol. The procedure is based on a [3+2] cycloaddition of a cholesterol possessing a side-chain terminal azide with a terminal acetylene.

Supporting Information

 
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