Synthesis 2015; 47(16): 2407-2413
DOI: 10.1055/s-0034-1381046
special topic
© Georg Thieme Verlag Stuttgart · New York

Leuckart–Wallach Approach to Sugar Isocyanides and Its IMCRs

Constantinos G. Neochoritis
University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands   Email: a.s.s.domling@rug.nl   URL: www.drugdesign.nl
,
Ji Zhang
University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands   Email: a.s.s.domling@rug.nl   URL: www.drugdesign.nl
,
Alexander Dömling*
University of Groningen, Department of Drug Design, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands   Email: a.s.s.domling@rug.nl   URL: www.drugdesign.nl
› Author Affiliations
Further Information

Publication History

Received: 16 April 2015

Accepted after revision: 20 June 2015

Publication Date:
03 August 2015 (eFirst)

Abstract

We utilize our recently introduced Leuckart–Wallach approach to synthesize anomeric sugar isocyanides in good overall yields and two steps. Moreover, we show the general usage of these isocyanides in isocyanide-based multicomponent reactions (IMCRs) to produce eight different compounds/scaffolds.

 
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