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Synthesis 2015; 47(20): 3169-3178
DOI: 10.1055/s-0034-1381040
DOI: 10.1055/s-0034-1381040
paper
Preparation of 2,3-Disubstituted 5-Bromo-1H-pyrrolo[2,3-b]pyridine Framework by Fischer Cyclization
Further Information
Publication History
Received: 18 April 2015
Accepted after revision: 14 May 2015
Publication Date:
15 July 2015 (online)
Abstract
A simple synthesis of some hard-to-reach heterocycles containing 2,3-disubstituted 5-bromo-1H-pyrrolo[2,3-b]pyridine framework by Fisсher indole cyclization in polyphosphoric acid has been developed. A particularly valuable feature of this synthetic route is the possibility to build a 5-bromo-7-azaindole scaffold with alkyl or aryl substituents at positions 2 and 3 from available starting materials.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1381040.
- Supporting Information
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