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Synthesis 2015; 47(21): 3292-3300
DOI: 10.1055/s-0034-1381009
DOI: 10.1055/s-0034-1381009
paper
An Approach to the Synthesis of Pyrimido[b]azepines via Ruthenium-Catalyzed Ring-Closing Metathesis
Further Information
Publication History
Received: 29 March 2015
Accepted after revision: 17 May 2015
Publication Date:
24 July 2015 (online)
Abstract
A highly efficient approach to the synthesis of a series of pyrimido[b]azepines has been developed with 5-allyl-2,4,6-trichloropyrimidine as the starting material in six or seven steps via a ring-closing metathesis (RCM) reaction. The absolute configuration of the key intermediate pyrimido[4,5-b]azepine was ascertained by X-ray crystal structure analysis.
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