Synthesis 2015; 47(08): 1085-1090
DOI: 10.1055/s-0034-1380162
psp
© Georg Thieme Verlag Stuttgart · New York

A Practical Route for the Preparation of Bis(2,2,2-trifluoroethyl) 2-Oxoalkylphosphonates

Katalin Molnár*
a  Prostaglandin Business Unit, Sanofi, Tó street 1-5, 1045 Budapest, Hungary   Email: [email protected]
,
László Takács
a  Prostaglandin Business Unit, Sanofi, Tó street 1-5, 1045 Budapest, Hungary   Email: [email protected]
,
Mihály Kádár
a  Prostaglandin Business Unit, Sanofi, Tó street 1-5, 1045 Budapest, Hungary   Email: [email protected]
,
Zsuzsanna Kardos
a  Prostaglandin Business Unit, Sanofi, Tó street 1-5, 1045 Budapest, Hungary   Email: [email protected]
,
Ferenc Faigl
b  MTA-BME Organic Chemical Technology Research Group, Hungarian Academy of Sciences, Budapest University of Technology and Economics, Budapest, Budafoki street 8, 1111, Hungary
› Author Affiliations
Further Information

Publication History

Received: 28 November 2014

Accepted after revision: 23 January 2015

Publication Date:
25 February 2015 (online)


Abstract

A generally applicable, practical route was developed for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates starting from the corresponding dimethyl 2-oxoalkylphosphonates. The three-step procedure contains mild and easily scaled up transformations such as trimethylsilylation, chlorination with oxalyl chloride, and trifluoroethylation; the overall yield is ca. 50%.

Supporting Information

 
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