Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(08): 1190-1194
DOI: 10.1055/s-0034-1380109

paper

© Georg Thieme Verlag Stuttgart · New York

Zolimidine Analogues: The Synthesis of Imidazo[1,2-α]pyridine-Based Sulfilimines and Sulfoximines

Authors

Christine M. M. Hendriks

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany eMail: carsten.bolm@oc.rwth-aachen.de
Pinchas Nürnberg

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany eMail: carsten.bolm@oc.rwth-aachen.de
Carsten Bolm*

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany eMail: carsten.bolm@oc.rwth-aachen.de

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Abstract

Zolimidine is a methylsulfonyl-substituted drug with an imidazo[1,2-α]pyridine core used for the treatment of peptic ulcer. Herein, we report the synthesis of unprecedented N-acetylsulfilimine and -sulfoximine analogues under mild conditions. Deprotection of the N-acetylsulfoximine allows the preparation of the corresponding NH-sulfoximine.

Key words

Key words

imidazo[1,2-α]pyridine - sulfoximine - sulfilimine - zolimidine - imination

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Zusatzmaterial

Supporting Information (PDF)