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Synthesis 2015; 47(04): 562-568
DOI: 10.1055/s-0034-1379584
DOI: 10.1055/s-0034-1379584
paper
Copper(I) Iodide Catalyzed Synthesis of Fused Hexacyclic Pyrazolo[4,5,1-de]quinolino[4,3,2-mn]acridin-14(11H)-ones under Ligand-Free Conditions
Further Information
Publication History
Received: 21 August 2014
Accepted after revision: 31 October 2014
Publication Date:
14 November 2014 (online)
Abstract
The three-component reaction of an o-halogenated benzaldehyde, 1H-indazol-6-amine, and cyclohexane-1,3-dione is described for the construction of fused hexacycles catalyzed by copper(I) iodide under ligand-free conditions. This is a domino reaction that constructs two new heterocycles and six new bonds in a one-pot reaction, and provides an efficient method for the synthesis of pyrazolo[4,5,1-de]quinolino[4,3,2-mn]acridin-14(11H)-ones in good yields.
Key words
1H-indazol-6-amine - pyrazoloquinolinoacridine - domino reaction - copper(I) iodide - ligand-freeSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379584. Included are copies of the 1H NMR and 13C NMR spectra for compounds 4a–t.
- Supporting Information
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