Palladium-Catalyzed Alcoholysis of 3-Iodopropynamides: Selective Synthesis of Carbamoylacetates

Jian-Sheng Tang; Can-Cheng Guo

doi:10.1055/s-0034-1379104

Synthesis, Table of Contents

Synthesis 2015; 47(01): 108-112
DOI: 10.1055/s-0034-1379104

paper

Palladium-Catalyzed Alcoholysis of 3-Iodopropynamides: Selective Synthesis of Carbamoylacetates

Authors

Jian-Sheng Tang

^aCollege of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China Fax: +86(731)88821488 Email: ccguo@hnu.edu.cn

^bLaboratory of Organic Chemistry, Hunan First Normal University, Changsha 410205, P. R. of China
Can-Cheng Guo*

^aCollege of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. of China Fax: +86(731)88821488 Email: ccguo@hnu.edu.cn

Abstract

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Abstract

A novel and selective method for the synthesis of carbamoylacetates via the alcoholysis of 3-iodopropynamides has been developed. 3-Iodopropynamides react with alcohols in the presence of palladium(II) acetate and DABCO to afford the corresponding carbamoylacetates in moderate to good yields.

Key words

palladium - 1,4-diazabicyclo[2.2.2]octane - alcoholysis - 3-iodopropynamides - carbamoylacetates

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References

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Supplementary Material

Supporting Information (PDF)