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Synthesis 2015; 47(22): 3473-3478
DOI: 10.1055/s-0034-1378787
DOI: 10.1055/s-0034-1378787
paper
Synthesis of Imidazole Derivatives by Cascade Reaction: Base-Mediated Addition/Alkyne Hydroamination of Propargylamines and Carbodiimides
Further Information
Publication History
Received: 16 February 2015
Accepted after revision: 04 June 2015
Publication Date:
12 August 2015 (online)
Abstract
A novel synthesis of 2-iminoimidazoles and 2-aminoimidazoles, via nucleophilic addition and a subsequent sodium hydroxide mediated intramolecular alkyne hydroamination from propargylamines and carbodiimides, is developed. This transition-metal-free cascade process represents an atom-economic and step-economic procedure for the construction of imidazole derivatives with high regioselectivity and moderate to good yields.
Key words
alkyne hydroamination - transition-metal-free - carbodiimides - imidazole synthesis - cascade processSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378787.
- Supporting Information
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