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Synlett 2015; 26(01): 36-39
DOI: 10.1055/s-0034-1378651
DOI: 10.1055/s-0034-1378651
cluster
Recent Advances in the Synthesis of Difluoromethylated Arenes
Further Information
Publication History
Received: 16 July 2014
Accepted: 24 July 2014
Publication Date:
21 August 2014 (online)
Abstract
The growing importance of fluorinated compounds in pharmaceuticals, agrochemicals, and materials has triggered the development of new methods for the introduction of fluorine into small molecules. Although it is a challenge to prepare fluorinated compounds, new developed reactions are addressing this challenge and facilitating the synthesis of difluoromethylated arenes. In this article, we highlight recently important developments in the synthesis of difluoromethylated arenes.
1 Introduction
2 Cross-Coupling with Copper
3 Cross-Coupling with Palladium
4 Cross-Coupling with Other Metals
5 C(sp2)–H Activation
6 C(sp3)–H Activation
7 Conclusion
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