A Concise Synthesis of 1-Oxygenated Carbazole Alkaloids, Clausine E and Clausine F

Abstract

A rapid entry into naturally occurring and biologically important 1-oxygenated carbazole clausine E was established through Wittig reaction and annulation. Further O-prenylation of clausine E by Mitsunobu reaction followed by p-Claisen rearrangement delivered clausine F.

Key words

alkaloids - Wittig reaction - annulation - Mitsunobu reaction - p-Claisen rearrangement

• References

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