Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents

U. Abu Mohsen; L. Yurttaş; U. Acar; Y. Özkay; Z. A. Kaplacikli; H. Karaca Gencer; Z Cantürk

doi:10.1055/s-0034-1377004

Drug Research, Table of Contents

Drug Res (Stuttg) 2015; 65(05): 266-271
DOI: 10.1055/s-0034-1377004

Original Article

Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents

U. Abu Mohsen

¹Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Azhar University, Gaza, Palestine

,

L. Yurttaş

²Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey

,

U. Acar

²Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey

,

Y. Özkay

²Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey

,

Z. A. Kaplacikli

²Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey

,

H. Karaca Gencer

³Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, Eskisehir, Turkey

,

Z Cantürk

³Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, Eskisehir, Turkey

› Author Affiliations

Abstract

In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]-substituted benzamide derivatives were synthesized by reacting 2,3-bis(4-methoxyphenyl)-6-aminoquinoxaline or 2,3-bis(4-methylphenyl)-6-aminoquinoxaline with benzoyl chloride derivatives in tetrahydrofuran and investigated for their antimicrobial activity. The structures of the obtained final compounds were confirmed by spectral data (IR, ¹H-NMR, ¹³C-NMR and MS). The antimicrobial activity of the compounds were determined by using the microbroth dilution method. Antimicrobial activity results revealed that synthesized compounds exhibited remarkable activity against Candida krusei (ATCC 6258) and Candida parapsilosis (ATCC 22019).

Key words

quinoxaline - amide - antimicrobial activity

Full Text

References

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