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Drug Res (Stuttg) 2015; 65(05): 266-271
DOI: 10.1055/s-0034-1377004
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents

U. Abu Mohsen
1   Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Al-Azhar University, Gaza, Palestine
,
L. Yurttaş
2   Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey
,
U. Acar
2   Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey
,
Y. Özkay
2   Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey
,
Z. A. Kaplacikli
2   Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey
,
H. Karaca Gencer
3   Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, Eskisehir, Turkey
,
Z Cantürk
3   Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Anadolu University, Eskisehir, Turkey
› Author Affiliations
Further Information

Publication History

received 27 March 2014

accepted 09 May 2014

Publication Date:
11 June 2014 (online)

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Abstract

In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]-substituted benzamide derivatives were synthesized by reacting 2,3-bis(4-methoxyphenyl)-6-aminoquinoxaline or 2,3-bis(4-methylphenyl)-6-aminoquinoxaline with benzoyl chloride derivatives in tetrahydrofuran and investigated for their antimicrobial activity. The structures of the obtained final compounds were confirmed by spectral data (IR, 1H-NMR, 13C-NMR and MS). The antimicrobial activity of the compounds were determined by using the microbroth dilution method. Antimicrobial activity results revealed that synthesized compounds exhibited remarkable activity against Candida krusei (ATCC 6258) and Candida parapsilosis (ATCC 22019).

Key words

quinoxaline - amide - antimicrobial activity
 

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