Z Gastroenterol 2014; 52 - A39
DOI: 10.1055/s-0034-1376099

Incidence rates and disease course of pediatric inflammatory bowel diseases in western Hungary between 1977 – 2011

B Lovász 1, L Lakatos 2, Á Horváth 3, T Pandúr 2, Z Erdélyi 2, M Balogh 4, I Szipocs 5, Z Végh 2, G Veres 6, P Golovics 1, L Kiss 1, M Mandel 1, P Lakatos 1
  • 11st Department of Medicine, Semmelweis University, Budapest, Hungary
  • 2Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary
  • 3Department of Pediatrics, Csolnoky F. Province Hospital, Veszprem, Hungary
  • 4Department of Medicine, Grof Eszterhazy Hospital, Papa, Hungary
  • 5Department of Medicine, Municipal Hospital, Tapolca, Hungary
  • 61st Department of Pediatrics, Semmelweis University, Budapest, Hungary

Background and Aims: Limited data are available on pediatric inflammatory bowel diseases in Eastern Europe. Our aim was to analyze disease characteristic in the populationbased Veszprem province database between 1977 – 2011.

Methods:187 (10.5%, ulcerative colitis/Crohn's disease/undetermined colitis:88/95/4) of 1565 incident patients were diagnosed with a pediatric onset in this population-based prospective inception cohort.

Results: The incidence of Crohn's disease and ulcerative colitis increased from 0 and 0.7 in 1977 – 1981 to 7.2 and 5.2 in 2007 – 2011 per 100.000 person years. Ileocolonic location (45%), inflammatory disease behaviour (61%) was the most frequent, in Crohn's disease, while azathioprine use was frequent (66%) and surgical resection rates were high (33% at 5 years) in pediatric-onset cases. In ulcerative colitis, 34% of patients were diagnosed with extensive disease, with high rates of disease extension (26% and 41% at 5 and 10 years), fulminant episodes (19.3%) and systemic steroid use (52.3%). The cumulative rate of colectomy rate was low (6.9%).

Conclusions: The incidence of pediatric inflammatory bowel diseases has rapidly increased in the last three decades in Western Hungary. Ileocolonic disease and need for azathioprine were characteristic in pediatric Crohn's disease, while pediatric onset ulcerative colitis was characterized by extensive disease and disease extension while the need for colectomy was low.