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Exp Clin Endocrinol Diabetes 2014; 122(06): 363-367
DOI: 10.1055/s-0034-1375647
Article
© Georg Thieme Verlag KG Stuttgart · New York

Impact of Age and Metabolic Syndrome on the Adipokine Profile in Childhood and Adult Obesity

D. Weghuber   *
1   Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria
,
H. Mangge   *
2   Clinical Institute of Medical and Chemical Laboratory Diagnostics Research, Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Medical University of Graz, Austria
,
E. Hochbrugger
3   Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Austria
,
T. M. Stulnig
3   Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Austria
4   Christian Doppler Laboratory for Cardio-Metabolic Immunotherapy, Department of Medicine III, Medical University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

received 12 January 2014
first decision 12 March 2014

accepted 17 April 2014

Publication Date:
18 June 2014 (online)

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Abstract

Objective: Obesity triggers an inflammatory response characterized by elevated circulating pro-inflammatory adipokines that predisposes to T2DM and cardiovascular disease. The objective of our study was to determine a potential association of adipokine plasma profile and the presence of a MetS in obese children and adolescents compared to adults.

Design and Methods: We determined serum levels of the adipokines soluble CD163 (sCD163), fetuin-A, osteopontin (OPN) and interleukin-1 receptor antagonist (IL-1 Ra) in 30 pediatric and 36 adult obese patients in a cross-sectional study.

Results: Serum concentrations of all tested adipokines except sCD163 were significantly elevated in the pediatric cohort compared to adults. Patients with MetS showed increased serum levels of sCD163, fetuin-A and IL-1 Ra levels compared to those without MetS. Fetuin-A and sCD163 remained significantly elevated by MetS within the juvenile group and borderline significant in the adults when tested separately. In the pediatric cohort we found correlations between sCD163 and fetuin-A as well as OPN and IL-1 Ra whereas correlations of sCD163 and both fetuin-A and IL-1 Ra were found in the adult group.

Conclusion: Our results indicate that adipokine profiles related to the presence of MetS significantly differ between pediatric and adult patients which may point to different underlying mechanisms.

Key words

pediatric obesity - adipokines - osteopontin - metabolic syndrome

* DW and HM equally contributed to this manuscript.


 

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