Intracytoplasmic Sperm Injection Indications: How Rigorous?

Samir N. Babayev; Chan Woo Park; Orhan Bukulmez

doi:10.1055/s-0034-1375180

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2014; 32(04): 283-290
DOI: 10.1055/s-0034-1375180

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Intracytoplasmic Sperm Injection Indications: How Rigorous?

Samir N. Babayev

¹Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas

,

Chan Woo Park

¹Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas

²Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea

,

Orhan Bukulmez

¹Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas

› Institutsangaben

Abstract

Up to 15% of all couples of reproductive age are diagnosed with subfertility and about one-third of those will have male factor infertility as a contributing factor. Intracytoplasmic sperm injection (ICSI) has proven to be invaluable for couples with severely compromised semen parameters. Since its introduction into the clinical practice in 1992, the indications for ICSI were dramatically expanded to include various patient populations with normal or mildly abnormal semen parameters. Moreover, some fertility programs choose to perform ICSI for all of their patients needing assisted reproductive technologies. By all means, the male factor indications for ICSI are not well defined, apart from its absolute utility with surgically obtained spermatozoa in the presence of low motility, or in cases of severe defects with sperm concentration and motility. Based on current evidence, ICSI is not indicated for routine use. Its adoption for previous history of total fertilization failure, in vitro oocyte maturation, cryopreserved oocytes, polyploidy prevention, poor-quality oocytes, diminished ovarian reserve, and advanced reproductive age are not supported by current evidence, albeit further research with well-designed studies is warranted. Finally, from a biological standpoint ICSI is considered to be more invasive, more energy consuming for the oocyte itself and its adverse genetic and epigenetic effects cannot be ruled out. Although more studies are needed to clarify definitive indications for ICSI, many of its current applications can be deemed empiric at this time.

Keywords

intracytoplasmic sperm injection - ICSI - in vitro fertilization - IVF - conventional IVF - assisted reproductive technology - ART - indications

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Referenzen

References
1 Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 1992; 340 (8810) 17-18
2 Van Steirteghem AC, Nagy Z, Joris H , et al. High fertilization and implantation rates after intracytoplasmic sperm injection. Hum Reprod 1993; 8 (7) 1061-1066
3 Tournaye H. Male factor infertility and ART. Asian J Androl 2012; 14 (1) 103-108
4 Cooper TG, Noonan E, von Eckardstein S , et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16 (3) 231-245
5 Cohlen BJ, Vandekerckhove P, te Velde ER, Habbema JD. Timed intercourse versus intra-uterine insemination with or without ovarian hyperstimulation for subfertility in men. Cochrane Database Syst Rev 2000; (2) CD000360
6 Ombelet W, Vandeput H, Van de Putte G , et al. Intrauterine insemination after ovarian stimulation with clomiphene citrate: predictive potential of inseminating motile count and sperm morphology. Hum Reprod 1997; 12 (7) 1458-1463
7 Goverde AJ, McDonnell J, Vermeiden JP, Schats R, Rutten FF, Schoemaker J. Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis. Lancet 2000; 355 (9197) 13-18
8 Kastrop PM, Weima SM, Van Kooij RJ, Te Velde ER. Comparison between intracytoplasmic sperm injection and in-vitro fertilization (IVF) with high insemination concentration after total fertilization failure in a previous IVF attempt. Hum Reprod 1999; 14 (1) 65-69
9 Verheyen G, Tournaye H, Staessen C, De Vos A, Vandervorst M, Van Steirteghem A. Controlled comparison of conventional in-vitro fertilization and intracytoplasmic sperm injection in patients with asthenozoospermia. Hum Reprod 1999; 14 (9) 2313-2319
10 Kruger TF, Menkveld R, Stander FS , et al. Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril 1986; 46 (6) 1118-1123
11 Gunalp S, Onculoglu C, Gurgan T, Kruger TF, Lombard CJ. A study of semen parameters with emphasis on sperm morphology in a fertile population: an attempt to develop clinical thresholds. Hum Reprod 2001; 16 (1) 110-114
12 Menkveld R, Wong WY, Lombard CJ , et al. Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds. Hum Reprod 2001; 16 (6) 1165-1171
13 Plachot M, Belaisch-Allart J, Mayenga JM, Chouraqui A, Tesquier L, Serkine AM. Outcome of conventional IVF and ICSI on sibling oocytes in mild male factor infertility. Hum Reprod 2002; 17 (2) 362-369
14 Tournaye H, Verheyen G, Albano C , et al. Intracytoplasmic sperm injection versus in vitro fertilization: a randomized controlled trial and a meta-analysis of the literature. Fertil Steril 2002; 78 (5) 1030-1037
15 Oehninger S, Acosta AA, Morshedi M , et al. Corrective measures and pregnancy outcome in in vitro fertilization in patients with severe sperm morphology abnormalities. Fertil Steril 1988; 50 (2) 283-287
16 Hall J, Fishel S, Green S , et al. Intracytoplasmic sperm injection versus high insemination concentration in-vitro fertilization in cases of very severe teratozoospermia. Hum Reprod 1995; 10 (3) 493-496
17 Keegan BR, Barton S, Sanchez X, Berkeley AS, Krey LC, Grifo J. Isolated teratozoospermia does not affect in vitro fertilization outcome and is not an indication for intracytoplasmic sperm injection. Fertil Steril 2007; 88 (6) 1583-1588
18 Mansour RT, Aboulghar MA, Serour GI, Amin YM, Ramzi AM. The effect of sperm parameters on the outcome of intracytoplasmic sperm injection. Fertil Steril 1995; 64 (5) 982-986
19 Robinson JN, Lockwood GM, Dokras A , et al. Does isolated teratozoospermia affect performance in in-vitro fertilization and embryo transfer?. Hum Reprod 1994; 9 (5) 870-874
20 Bartoov B, Berkovitz A, Eltes F , et al. Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection. Fertil Steril 2003; 80 (6) 1413-1419
21 Leandri RD, Gachet A, Pfeffer J , et al. Is intracytoplasmic morphologically selected sperm injection (IMSI) beneficial in the first ART cycle? a multicentric randomized controlled trial. Andrology 2013; 1 (5) 692-697
22 Zini A, Fahmy N, Belzile E, Ciampi A, Al-Hathal N, Kotb A. Antisperm antibodies are not associated with pregnancy rates after IVF and ICSI: systematic review and meta-analysis. Hum Reprod 2011; 26 (6) 1288-1295
23 Society for Assisted Reproductive Technology National Data Summary, 2011. Available at: http://www.sartcorsonline.com/rptCSR_PublicMultYear.aspx?ClinicPKID=0 . Accessed December 1, 2013
24 Tucker M, Graham J, Han T, Stillman R, Levy M. Conventional insemination versus intracytoplasmic sperm injection. Lancet 2001; 358 (9293) 1645-1646
25 Bhattacharya S, Hamilton MP, Shaaban M , et al. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial. Lancet 2001; 357 (9274) 2075-2079
26 Molloy D, Harrison K, Breen T, Hennessey J. The predictive value of idiopathic failure to fertilize on the first in vitro fertilization attempt. Fertil Steril 1991; 56 (2) 285-289
27 Roest J, Van Heusden AM, Zeilmaker GH, Verhoeff A. Treatment policy after poor fertilization in the first IVF cycle. J Assist Reprod Genet 1998; 15 (1) 18-21
28 van der Westerlaken L, Helmerhorst F, Dieben S, Naaktgeboren N. Intracytoplasmic sperm injection as a treatment for unexplained total fertilization failure or low fertilization after conventional in vitro fertilization. Fertil Steril 2005; 83 (3) 612-617
29 Kinzer DR, Barrett CB, Powers RD. Prognosis for clinical pregnancy and delivery after total fertilization failure during conventional in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril 2008; 90 (2) 284-288
30 Tomás C, Orava M, Tuomivaara L, Martikainen H. Low pregnancy rate is achieved in patients treated with intracytoplasmic sperm injection due to previous low or failed fertilization in in-vitro fertilization. Hum Reprod 1998; 13 (1) 65-70
31 Practice Committees of the American Society for Reproductive Medicine and Society for Assisted Reproductive Technology. Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: a committee opinion. Fertil Steril 2012; 98 (6) 1395-1399
32 Park KS, Song HB, Chun SS. Late fertilization of unfertilized human oocytes in in vitro fertilization and intracytoplasmic sperm injection cycles: conventional insemination versus ICSI. J Assist Reprod Genet 2000; 17 (8) 419-424
33 Tsirigotis M, Nicholson N, Taranissi M, Bennett V, Pelekanos M, Craft I. Late intracytoplasmic sperm injection in unexpected failed fertilization in vitro: diagnostic or therapeutic?. Fertil Steril 1995; 63 (4) 816-819
34 Plachot M, de Grouchy J, Junca AM, Mandelbaum J, Salat-Baroux J, Cohen J. Chromosome analysis of human oocytes and embryos: does delayed fertilization increase chromosome imbalance?. Hum Reprod 1988; 3 (1) 125-127
35 Practice Committee of the American Society for Reproductive Medicine. Effectiveness and treatment for unexplained infertility. Fertil Steril 2006; 86 (5) (Suppl. 01) S111-S114
36 Bungum L, Bungum M, Humaidan P, Andersen CY. A strategy for treatment of couples with unexplained infertility who failed to conceive after intrauterine insemination. Reprod Biomed Online 2004; 8 (5) 584-589
37 Johnson LN, Sasson IE, Sammel MD, Dokras A. Does intracytoplasmic sperm injection improve the fertilization rate and decrease the total fertilization failure rate in couples with well-defined unexplained infertility? A systematic review and meta-analysis. Fertil Steril 2013; 100 (3) 704-711
38 Moreno C, Ruiz A, Simón C, Pellicer A, Remohí J. Intracytoplasmic sperm injection as a routine indication in low responder patients. Hum Reprod 1998; 13 (8) 2126-2129
39 Luna M, Bigelow C, Duke M , et al. Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?. J Assist Reprod Genet 2011; 28 (10) 911-915
40 Borini A, Gambardella A, Bonu MA , et al. Comparison of IVF and ICSI when only few oocytes are available for insemination. Reprod Biomed Online 2009; 19 (2) 270-275
41 Gozlan I, Dor A, Farber B, Meirow D, Feinstein S, Levron J. Comparing intracytoplasmic sperm injection and in vitro fertilization in patients with single oocyte retrieval. Fertil Steril 2007; 87 (3) 515-518
42 Boyers SP, Diamond MP, Lavy G, Russell JB, DeCherney AH. The effect of polyploidy on embryo cleavage after in vitro fertilization in humans. Fertil Steril 1987; 48 (4) 624-627
43 Jun SH, O'Leary T, Jackson KV, Racowsky C. Benefit of intracytoplasmic sperm injection in patients with a high incidence of triploidy in a prior in vitro fertilization cycle. Fertil Steril 2006; 86 (4) 825-829
44 Shibahara H, Yamanaka H, Hirano Y , et al. Analysis of factors associated with multinucleate formation in human IVF. Int J Androl 2003; 26 (4) 211-214
45 Sauer MV, Chang PL. Establishing a clinical program for human immunodeficiency virus 1-seropositive men to father seronegative children by means of in vitro fertilization with intracytoplasmic sperm injection. Am J Obstet Gynecol 2002; 186 (4) 627-633
46 Mencaglia L, Falcone P, Lentini GM , et al. ICSI for treatment of human immunodeficiency virus and hepatitis C virus-serodiscordant couples with infected male partner. Hum Reprod 2005; 20 (8) 2242-2246
47 van Leeuwen E, Repping S, Prins JM, Reiss P, van der Veen F. Assisted reproductive technologies to establish pregnancies in couples with an HIV-1-infected man. Neth J Med 2009; 67 (8) 322-327
48 Semprini AE, Macaluso M, Hollander L , et al. Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner. Am J Obstet Gynecol 2013; 208 (5) e1-e9
49 Pasquier C, Daudin M, Righi L , et al. Sperm washing and virus nucleic acid detection to reduce HIV and hepatitis C virus transmission in serodiscordant couples wishing to have children. AIDS 2000; 14 (14) 2093-2099
50 Englert Y, Lesage B, Van Vooren JP , et al. Medically assisted reproduction in the presence of chronic viral diseases. Hum Reprod Update 2004; 10 (2) 149-162
51 Dore GJ, Kaldor JM. Detection of HCV RNA in semen. Lancet 2000; 356 (9240) 1520
52 Harton GL, De Rycke M, Fiorentino F , et al; European Society for Human Reproduction and Embryology (ESHRE) PGD Consortium. ESHRE PGD consortium best practice guidelines for amplification-based PGD. Hum Reprod 2011; 26 (1) 33-40
53 Fiorentino F, Biricik A, Karadayi H , et al. Development and clinical application of a strategy for preimplantation genetic diagnosis of single gene disorders combined with HLA matching. Mol Hum Reprod 2004; 10 (6) 445-460
54 Harper JC, Harton G. The use of arrays in preimplantation genetic diagnosis and screening. Fertil Steril 2010; 94 (4) 1173-1177
55 Walls M, Junk S, Ryan JP, Hart R. IVF versus ICSI for the fertilization of in-vitro matured human oocytes. Reprod Biomed Online 2012; 25 (6) 603-607
56 Söderström-Anttila V, Mäkinen S, Tuuri T, Suikkari AM. Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients. Hum Reprod 2005; 20 (6) 1534-1540
57 Gook DA, Schiewe MC, Osborn SM, Asch RH, Jansen RP, Johnston WI. Intracytoplasmic sperm injection and embryo development of human oocytes cryopreserved using 1,2-propanediol. Hum Reprod 1995; 10 (10) 2637-2641
58 Kazem R, Thompson LA, Srikantharajah A, Laing MA, Hamilton MP, Templeton A. Cryopreservation of human oocytes and fertilization by two techniques: in-vitro fertilization and intracytoplasmic sperm injection. Hum Reprod 1995; 10 (10) 2650-2654
59 Li XH, Chen SU, Zhang X , et al. Cryopreserved oocytes of infertile couples undergoing assisted reproductive technology could be an important source of oocyte donation: a clinical report of successful pregnancies. Hum Reprod 2005; 20 (12) 3390-3394
60 Gook DA, Edgar DH. Human oocyte cryopreservation. Hum Reprod Update 2007; 13 (6) 591-605
61 Yanagimachi R. Intracytoplasmic injection of spermatozoa and spermatogenic cells: its biology and applications in humans and animals. Reprod Biomed Online 2005; 10 (2) 247-288
62 Bukulmez O. Does assisted reproductive technology cause birth defects?. Curr Opin Obstet Gynecol 2009; 21 (3) 260-264
63 Bonduelle M, Joris H, Hofmans K, Liebaers I, Van Steirteghem A. Mental development of 201 ICSI children at 2 years of age. Lancet 1998; 351 (9115) 1553
64 Bonduelle M, Wilikens A, Buysse A , et al. A follow-up study of children born after intracytoplasmic sperm injection (ICSI) with epididymal and testicular spermatozoa and after replacement of cryopreserved embryos obtained after ICSI. Hum Reprod 1998; 13 (Suppl. 01) 196-207
65 Bowen JR, Gibson FL, Leslie GI, Saunders DM. Medical and developmental outcome at 1. year for children conceived by intracytoplasmic sperm injection. Lancet 1998; 351 (9115) 1529-1534
66 Palermo GD, Colombero LT, Schattman GL, Davis OK, Rosenwaks Z. Evolution of pregnancies and initial follow-up of newborns delivered after intracytoplasmic sperm injection. JAMA 1996; 276 (23) 1893-1897
67 Wennerholm UB, Bergh C, Hamberger L , et al. Incidence of congenital malformations in children born after ICSI. Hum Reprod 2000; 15 (4) 944-948
68 Leslie GI, Gibson FL, McMahon C, Cohen J, Saunders DM, Tennant C. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum Reprod 2003; 18 (10) 2067-2072
69 Katalinic A, Rösch C, Ludwig M ; German ICSI Follow-Up Study Group. Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertil Steril 2004; 81 (6) 1604-1616
70 Davies MJ, Moore VM, Willson KJ , et al. Reproductive technologies and the risk of birth defects. N Engl J Med 2012; 366 (19) 1803-1813