Am J Perinatol 2014; 31(07): 605-616
DOI: 10.1055/s-0034-1373842
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Tracheal Occlusion for Fetal Diaphragmatic Hernia

Saul Snowise
1  Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, The UT Health School of Medicine and the Texas Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas
,
Anthony Johnson
1  Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, The UT Health School of Medicine and the Texas Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas
› Author Affiliations
Further Information

Publication History

13 January 2014

21 February 2014

Publication Date:
16 May 2014 (eFirst)

Abstract

Despite advances in neonatal care, diaphragmatic hernia still inflicts significant morbidity and mortality on affected neonates. Abnormal embryologic events disrupt the formation of the diaphragm allowing the abdominal viscera to occupy the intrathoracic space. This interrupts normal pulmonary development with resulting pulmonary hypoplasia and pulmonary hypertension in neonatal survivors. This review will outline the relevant embryology, etiologies, and pertinent historical aspects of diaphragmatic hernia treatments to better understand the current antenatal approach to therapy for this disease process.