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Exp Clin Endocrinol Diabetes 2014; 122(06): 334-340
DOI: 10.1055/s-0034-1372581
Article
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Importance of Exercise in the Control of Metabolic and Inflammatory Parameters at the Moment of Onset in Type 1 Diabetic Subjects

T. Martínez-Ramonde
1   Endocrinology Service, University Hospital A Coruña (Spain)
,
N. Alonso
2   Applied Biology Department and Institute of Bioengineering, University Miguel Hernandez, Elche (Alicante) Spain
,
F. Cordido
1   Endocrinology Service, University Hospital A Coruña (Spain)
,
E. Cervelló
3   Sport Research Centre, University Miguel Hernandez, Elche (Alicante) Spain
,
A. Cañizares
4   Microbiology Department, University Hospital Complex, A Coruña (Spain)
,
P. Martínez-Peinado
5   Biotechnology Department, University of Alicante (Spain)
,
J. M. Sempere
5   Biotechnology Department, University of Alicante (Spain)
,
E. Roche
2   Applied Biology Department and Institute of Bioengineering, University Miguel Hernandez, Elche (Alicante) Spain
6   CIBERobn (Fisiopatología de la Obesidad y la Nutrición CB12/03/30038), Instituto de Salud Carlos III, Spain
› Author Affiliations
Further Information

Publication History

received 16 January 2014
first decision 04 March 2014

accepted 19 March 2014

Publication Date:
05 May 2014 (online)

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Abstract

The onset of type 1 diabetes coincides with the final phase of β-cell destruction. In some cases, this period is characterized by the presence of a functional reserve of β-cells, favouring an adequate metabolic control (honeymoon phase). Therefore, the extension of this situation could have evident benefits in subsequent diabetes management. We aimed to study the influence of regular physical activity before and after the onset of the disease. We did an observational study of 2 groups of type 1 diabetic patients from onset to a 2-year period. One group (n=8) exercised regularly (5 or more hours/week) before onset and continued doing so with the same regularity. The second group (n=11) either did not perform physical activity or did so sporadically. Circulating glycated haemoglobin (HbA1c), C-peptide, protein carbonyls and basal cytokine levels were determined at the beginning and at the end of the 1st and 2nd year. The more active group debuted with and maintained significantly lower HbA1c levels and insulin requirements compared to the more sedentary group. C-peptide levels were only significantly higher in the active group at the moment of onset compared to the sedentary group. In addition, determination of basal circulating cytokines revealed a large variability between individuals but no significant differences when comparing the groups. Altogether, the obtained results seem to indicate that physical activity allows a better control at the moment of onset regarding glycaemic control, residual endocrine pancreatic mass and subsequent insulin requirements.

Key words

C-peptide - β-cell mass - glycated haemoglobin - inflammation
 

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