J Neurol Surg B Skull Base 2014; 75 - A066
DOI: 10.1055/s-0034-1370472

Incidence and Survival Patterns of Sinonasal Undifferentiated Carcinoma in the United States

Kyle J. Chambers 1, Ashton Lehmann 1, Aaron Remenschneider 1, Matthew Dedmon 1, Bharat Yarlagadda 1, Stacey T. Gray 1, Derrrick T. Lin 1
  • 1Boston, USA

Objective: To determine trends in survival patterns for sinonasal undifferentiated carcinoma in the United States.

Design: From the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute, 1973–2010, all cases of sinonasal undifferentiated carcinoma between were examined. Age-adjusted incidence and survival rates were calculated and stratified by location and treatment. Additionally, survival trends over time were analyzed.

Setting: A national healthcare database.

Main Outcome Measures: Age-adjusted incidence and survival rates stratified by treatment.

Results: A total of 318 cases of sinonasal undifferentiated carcinoma were identified. Age-adjusted incidence rate (IR) was 0.02 per 100,000. Incidence was greater in males (IR = 0.028) than in females (IR = 0.013) (p-value = 0.04). Mean age of diagnosis was 57.8 years. Median survival was 22.1 months with overall 5-year and 10-year relative survival of 34.9% and 31.3%, respectively. Five-year relative survival for those that received surgery, radiation, and surgery combined with radiation was 38.7%, 36.0%, and 39.1%, respectively. Median survival for surgery combined with radiation was 41.9 months. Median survival from 1973–1986 and 1986–2010 was 14.5 months and 23.5 months, respectively.

Conclusions: This study provides new data regarding survival patterns of sinonasal undifferentiated carcinoma in the United States, confirming the survival benefit of surgery and radiation therapy and identifying a trend toward improvement in survival in recent decades.