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DOI: 10.1055/s-0034-1370472
Incidence and Survival Patterns of Sinonasal Undifferentiated Carcinoma in the United States
Objective: To determine trends in survival patterns for sinonasal undifferentiated carcinoma in the United States.
Design: From the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute, 1973–2010, all cases of sinonasal undifferentiated carcinoma between were examined. Age-adjusted incidence and survival rates were calculated and stratified by location and treatment. Additionally, survival trends over time were analyzed.
Setting: A national healthcare database.
Main Outcome Measures: Age-adjusted incidence and survival rates stratified by treatment.
Results: A total of 318 cases of sinonasal undifferentiated carcinoma were identified. Age-adjusted incidence rate (IR) was 0.02 per 100,000. Incidence was greater in males (IR = 0.028) than in females (IR = 0.013) (p-value = 0.04). Mean age of diagnosis was 57.8 years. Median survival was 22.1 months with overall 5-year and 10-year relative survival of 34.9% and 31.3%, respectively. Five-year relative survival for those that received surgery, radiation, and surgery combined with radiation was 38.7%, 36.0%, and 39.1%, respectively. Median survival for surgery combined with radiation was 41.9 months. Median survival from 1973–1986 and 1986–2010 was 14.5 months and 23.5 months, respectively.
Conclusions: This study provides new data regarding survival patterns of sinonasal undifferentiated carcinoma in the United States, confirming the survival benefit of surgery and radiation therapy and identifying a trend toward improvement in survival in recent decades.