Structure-Activity Relationship Study of Dibenzocyclooctadiene Lignans Isolated from Schisandra chinensis on Lipopolysaccharide-Induced Microglia Activation

Abstract

To explore the relationship of the dibenzocyclooctadiene lignans from Schisandra chinensis to their anti-inflammatory activities, series of dibenzocyclooctadiene lignans were isolated and assessed by testing their inhibitory effects on nitric oxide production in lipopolysaccharide-induced BV2 mouse microglia. It was found, for the first time, that dibenzocyclooctadiene lignans which have S-biphenyl and methylenedioxy groups strongly inhibited LPS-induced microglia activation. The methoxy group on the cyclooctadiene introduced more effectiveness, but the presence of an acetyl group on the cyclooctadiene or hydroxyl group on C-7 decreased the inhibitory activity.

Key words

Schisandra chinensis - Schisandraceae - dibenzocyclooctadiene lignans - microglia - nitric oxide - structure-activity relationship

• References

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