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Planta Med 2014; 80(08/09): 688-694
DOI: 10.1055/s-0034-1368456
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Horsfiequinones A–F, Dimeric Diarylpropanoids from Horsfieldia tetratepala

Qin Ma
1   School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China
,
Kang Min
2   Diqing Institute of Agricultural Science, Shangrila, Yunnan, China
,
Hao-Liang Li
1   School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China
,
Jin-He Jiang
1   School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China
,
Ying Liu
1   School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China
,
Rui Zhan
1   School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China
,
Ye-Gao Chen
1   School of Chemistry and Chemical Engineering, Yunnan Normal University, Chenggong New Development Area, Kunming, Yunnan, China
› Author Affiliations
Further Information

Publication History

received 06 January 2014
revised 10 April 2014

accepted 14 April 2014

Publication Date:
22 May 2014 (online)

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Abstract

A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B–F (2–6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B–F (2–6), isolated as enantiomer mixtures with unequal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC50 values ranging from 3.18 ± 0.67 to 6.61 ± 0.08 µM.

Key words

Horsfieldia tetratepala - Myristicaceae - diarylpropanoid - cytotoxicity

Supporting Information

 

  • References

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