Planta Med 2014; 80(08/09): 710-718
DOI: 10.1055/s-0034-1368455
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Triterpene Saponins from the Stems of Entada phaseoloides

Hui Xiong
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China
,
Xin Ding
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China
,
Xin-zhou Yang
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China
,
Guang-zhong Yang
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China
,
Zhi-nan Mei
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China
› Author Affiliations
Further Information

Publication History

received 08 October 2013
revised 22 March 2014

accepted 07 April 2014

Publication Date:
22 May 2014 (online)

Abstract

Ten new triterpene saponins (110) have been isolated from the stems of Entada phaseoloides. Their structures were elucidated by spectroscopic analysis and chemical methods. Among these compounds, the aglycons of 610 are being reported for the first time, in this study, including 3β,15α,16α-trihydroxy-11α,12α-epoxy olean-28,13β-olide (6), 3β,15α,16α-trihydroxy-11-oxo-olean-12-en-28-oic acids (7 and 8), and 3β,15α,16α-trihydroxy-oleana-11,13(18)-dien-28-oic acids (9 and 10). The cytotoxic activities of all of these compounds were evaluated against HepG-2, A549, and Ec-1 cell lines.

Supporting Information