Planta Med 2014; 80(07): 604-608
DOI: 10.1055/s-0034-1368427
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

α-Glucosidase Inhibitory Activities of Isoflavanones, Isoflavones, and Pterocarpans from Mucuna pruriens

Tshewang Dendup
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
,
Vilailak Prachyawarakorn
2   Chulabhorn Research Institute, Bangkok, Thailand
,
Acharavadee Pansanit
2   Chulabhorn Research Institute, Bangkok, Thailand
,
Chulabhorn Mahidol
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
2   Chulabhorn Research Institute, Bangkok, Thailand
,
Somsak Ruchirawat
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
2   Chulabhorn Research Institute, Bangkok, Thailand
3   Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand
,
Prasat Kittakoop
1   Chulabhorn Graduate Institute, Chemical Biology Program, Bangkok, Thailand
2   Chulabhorn Research Institute, Bangkok, Thailand
3   Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok, Thailand
› Institutsangaben
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Publikationsverlauf

received 05. September 2013
revised 07. März 2014

accepted 20. März 2014

Publikationsdatum:
29. April 2014 (online)

Abstract

Three new isoflavanones (13) and thirteen known compounds (416) were isolated from the roots of Mucuna pruriens. The absolute configurations of isoflavanones 13 and parvisoflavanone (4), lespedeol C (5), and uncinanone C (6) were addressed by a circular dichroism technique. Isoflavanones, isoflavones, and pterocarpans of M. pruriens were found to be α-glucosidase inhibitors. Medicarpin (7) and parvisoflavone B (9) were potent α-glucosidase inhibitors (twofold less active than the standard drug acarbose). The production of bioactive metabolites in M. pruriens seems to be season-dependent.

Supporting Information

 
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