Anti-inflammatory Terpenes from Flowers of Inula japonica

Abstract

Five new terpenes (1–5) and ten known compounds (6–15) were isolated from Inula japonica, and their structures were identified by spectroscopic analysis. Compounds 3 and 14 showed positive inhibitory effects on nitric oxide production. Furthermore, compound 14 suppressed both leukotriene C₄ synthesis and degranulation in c-kit ligand-induced bone marrow-derived mast cells.

Key words

Inula japonica - Compositae - terpene - anti-inflammatory - NO - LTC₄ - degranulation

• References

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