Similitude and Rebound Effect of Drugs

Summary

Samuel Hahnemann systematised the homeopathic model and the effects of drugs on the state of human health, describing a primary action of the drugs followed by a secondary and opposite action of the organism. In modern pharmacology, this secondary action is known as the rebound effect or paradoxical reaction of the organism, being described after the discontinuation of several classes of palliative (enantiopathic) drugs, i.e., those that act according to the principle of contrary (contraria contrariis curentur). Besides being able to cause severe and fatal iatrogenic events when appearing after the palliative use of modern drugs, the rebound effect might awaken a healing reaction if the very same drugs involved were employed according to the principle of similitude (similia similibus curentur).

Key words

Homeopathy - Pharmacology - Adverse effect - Secondary effect - Rebound effect - Paradoxical reaction - Law of similarity

• References

• 1 Teixeira MZ. Semelhante cura semelhante: o princípio de cura homeopático fundamentado pela racionalidade médica e científica [Similar cure similar: the principle of homeopathic cure based by medical and scientific rationality]. São Paulo: Editorial Petrus; 1998
• 2 Teixeira MZ. Similitude in modern pharmacology. Br Homeopath J 1999; 88: 112-120
• 3 Teixeira MZ. Evidence of the principle of similitude in modern fatal iatrogenic events. Homeopathy 2006; 95: 229-236
• 4 Teixeira MZ. NSAIDs, Myocardial infarction, rebound effect and similitude. Homeopathy 2007; 96: 67-68
• 5 Teixeira MZ. Bronchodilators, fatal asthma, rebound effect and similitude. Homeopathy 2007; 96: 135-137
• 6 Teixeira MZ. Antidepressants, suicidality and rebound effect: evidence of similitude?. Homeopathy 2009; 98: 114-121
• 7 Teixeira MZ. Statins withdrawal, vascular complications, rebound effect and similitude. Homeopathy 2010; 99: 255-262
• 8 Teixeira MZ. Rebound acid hypersecretion after withdrawal of gastric acid suppressing drugs: new evidence of similitude. Homeopathy 2011; 100: 148-156
• 9 Teixeira MZ. Rebound effect of drugs: fatal risk of conventional treatment and pharmacological basis of homeopathic treatment. Int J High Dilution Res 2012; 11: 69-106
• 10 Teixeira MZ. Antiresorptive drugs (bisphosphonates), atypical fractures and rebound effect: new evidence of similitude. Homeopathy 2012; 101: 231-242
• 11 Teixeira MZ. Immunomodulatory drugs (natalizumab), worsening of multiple sclerosis, rebound effect and similitude. Homeopathy 2013; 102: 215-224
• 12 Teixeira MZ. Homeopathic use of modern medicines: utilisation of the curative rebound effect. Med Hypotheses 2003; 60: 276-283
• 13 Teixeira MZ. “Paradoxical strategy for treating chronic diseases”: a therapeutic model used in homeopathy for more than two centuries. Homeopathy 2005; 94: 265-266
• 14 Teixeira MZ. New homeopathic medicines: use of modern drugs according to the principle of similitude. Homeopathy 2011; 100: 244-252
• 15 Teixeira MZ. Homeopathic use of modern drugs: therapeutic application of the organism paradoxical reaction or rebound effect. Int J High Dilution Res 2011; 10: 338-352
• 16 Teixeira MZ. “New Homeopathic Medicines” database: a project to employ conventional drugs according to the homeopathic method of treatment. Eur J Integr Med 2013; 5: 270-278