Isolation and Immunosuppressive Effects of 6″-O-Acetylginsenoside Rb1
                    Extracted from North American Ginseng

Raziye Samimi; William Z. Xu; Edmund M. K. Lui; Paul A. Charpentier

doi:10.1055/s-0034-1368319

Planta Medica, Inhaltsverzeichnis

Planta Med 2014; 80(06): 509-516
DOI: 10.1055/s-0034-1368319

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Isolation and Immunosuppressive Effects of 6″-O-Acetylginsenoside Rb₁ Extracted from North American Ginseng

Raziye Samimi

¹Department of Chemical and Biochemical Engineering, Western University, London, Canada

³The Ontario Ginseng Innovation & Research Consortium, London, Canada

,

William Z. Xu

¹Department of Chemical and Biochemical Engineering, Western University, London, Canada

,

Edmund M. K. Lui

²Department of Physiology and Pharmacology, Western University, London, Canada

³The Ontario Ginseng Innovation & Research Consortium, London, Canada

,

Paul A. Charpentier

¹Department of Chemical and Biochemical Engineering, Western University, London, Canada

³The Ontario Ginseng Innovation & Research Consortium, London, Canada

› Institutsangaben

Abstract

Extraction of medicinally active components from natural health products has become an emerging source for drug discovery. Of particular interest for this work was the finding and testing of a new ginsenoside from North American ginseng (Panax quinquefolius). In the present study, a large amount of 6″-O-acetylginsenoside Rb₁, compound 7, was found using ultrasonic extraction of North American ginseng with DMSO aqueous solution. This new ginsenoside was well identified with MS, FTIR, and 1D (¹H and ¹³C) and 2D (gCOSY, gHSQC, and gHMBC) NMR. Subsequent bioassay experiments confirmed that compound 7 demonstrated an additional immunosuppressive activity towards inhibiting the production of nitric oxide and tumor necrosis factor alpha in lipopolysaccharide-induced macrophage cells in a dose-dependent manner using murine macrophages. This new ginsenoside is encouraging for the further exploration and development of novel drugs.

Key words

Panax quinquefolius - Araliaceae - DMSO - immunosuppressive - 6″-O-acetylginsenoside Rb₁ - saponin

Volltext

Referenzen

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Zusatzmaterial

Supporting Information

Isolation and Immunosuppressive Effects of 6″-O-Acetylginsenoside Rb1 Extracted from North American Ginseng

Isolation and Immunosuppressive Effects of 6″-O-Acetylginsenoside Rb₁ Extracted from North American Ginseng