Aggressive Breast Cancer during Pregnancy with a Rare Form of Metastasis in the Maternal Placenta

Abstract

Breast cancer is the second most common cancer diagnosed during pregnancy. Here we describe a 29-year-old patient with a recurrence of breast cancer with simultaneous brain, pulmonary and placenta metastasis. An overview of the literature on placenta metastases is provided together with a report on the interdisciplinary medical management.

Zusammenfassung

Das Mammakarzinom ist die zweithäufigste Krebserkrankung, die während der Schwangerschaft diagnostiziert wird. Wir beschreiben hier eine 29-jährige Patientin, die ein Rezidiv eines Mammakarzinoms mit einer synchronen Hirn-, Lungen- und Plazentametastasierung aufweist. Es wird ein Literaturüberblick über Plazentametastasen gegeben sowie über das interdisziplinäre medizinische Management berichtet.

Key words

breast cancer - pregnancy - placenta metastasis

Schlüsselwörter

Mammakarzinom - Schwangerschaft - Plazentametastase

• Literature

• 1 Barnes DM, Newman LA. Pregnancy-associated breast cancer: a literature review. Surg Clin North Am 2007; 87: 417-430
• 2 Guinee VF, Olsson H, Möller T et al. Effect of pregnancy on prognosis for young women with breast cancer. Lancet 1994; 343: 1587-1589
• 3 Upponi SS, Ahmad F, Whitaker IS et al. Pregnancy after breast cancer. Eur J Cancer 2003; 39: 736-741
• 4 von Schoultz E, Johansson H, Wilking N et al. Influence of prior and subsequent pregnancy on breast cancer prognosis. J Clin Oncol 1995; 13: 430-434
• 5 Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol 2003; 101: 178-193
• 6 Han SN, Kesic VI, Van Calsteren K et al. ESGO ‘Cancer in Pregnancy’ Task Force. Cancer in pregnancy: a survey of current clinical practice. Eur J Obstet Gynecol Reprod Biol 2013; 167: 18-23
• 7 Kal HB, Struikmans H. Radiotherapy during pregnancy: fact and fiction. Lancet Oncol 2005; 6: 328-333
• 8 Nakagawa K, Aoki Y, Kusama T et al. Radiotherapy during pregnancy: effects on fetuses and neonates. Clin Ther 1997; 19: 770-777
• 9 Bader AA, Schlembach D, Tamussino KF et al. Anhydramnios associated with administration of trastuzumab and paclitaxel for metastatic breast cancer during pregnancy. Lancet Oncol 2007; 8: 79-81
• 10 Shrim A, Garcia-Bournissen F, Maxwell C et al. Trastuzumab treatment for breast cancer during pregnancy. Can Fam Physician 2008; 54: 31-32
• 11 Mandrawa CL, Stewart J, Fabinyi GC et al. A case study of trastuzumab treatment for metastatic breast cancer in pregnancy: fetal risks and management of cerebral metastases. Aust N Z J Obstet Gynaecol 2011; 51: 372-376
• 12 Monteiro DL, Trajano AJ, Menezes DC et al. [Breast cancer during pregnancy and chemotherapy: a systematic review]. Rev Assoc Med Bras 2013; 59: 174-180
• 13 Cardonick E, Bhat A, Gilmandyar D et al. Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy: case series and review of the literature. Ann Oncol 2012; 23: 3016-3023
• 14 Alexander A, Samlowski WE, Grossman D et al. Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant. J Clin Oncol 2003; 21: 2179-2186
• 15 Ben Brahim E, Mrad K, Driss M et al. Placental metastasis of breast cancer. Gynecol Obstet Fertil 2001; 29: 545-548
• 16 Catlin EA, Roberts jr. JD, Erana R et al. Transplacental transmission of natural-killer-cell lymphoma. N Engl J Med 1999; 341: 85-91
• 17 Jackisch C, Louwen F, Schwenkhagen A et al. Lung cancer during pregnancy involving the products of conception and a review of the literature. Arch Gynecol Obstet 2003; 268: 69-77
• 18 Loibl S, Han SN, von Minckwitz G et al. Treatment of breast cancer during pregnancy: an observational study. Lancet Oncol 2012; 13: 887-896
• 19 Tartakover-Matalon S, Mizrahi A, Epstein G et al. Breast cancer characteristics are modified by first trimester human placenta: in vitro co-culture study. Hum Reprod 2010; 25: 2441-2454