Abstract
Background Aortic aneurysms are vascular diseases that are associated with high mortality and
morbidity. Cytochrome P450 CYP1A1 and glutathione S-transferase (GSTP1) isozymes were
searched and compared with the patients who had experienced aortic surgery due to
aortic aneurysm and atherosclerotic patients without aneurysm to find the relation
of the oxidative stress with the aneurysms.
Materials and Methods Study group consisted of the patients with the diagnosis of aortic aneurysm (group
I, n: 12) and control group who were operated for coronary bypass surgery: preoperatively
drug users (group II, n: 21) and nonusers (group III, n: 15). Paraffin sections (4 μm thick) of aortic biopsy materials were stained with
hematoxylin and eosine, CYP1A1 and GSTP1 immunohistochemical markers. The specimens
were evaluated using light microscopy at 40- to 400-fold magnification.
Results The expressions of CYP1A1 and GSTP1 isozymes were found statistically significantly
higher in the patients who have an aortic aneurysm than both the control groups (p < 0.05). There was no significant association between protein expressions, drugs
and duration of usage, patient's demographic variables, and smoking (p > 0.05).
Conclusions In this pioneering study, CYP1A1 and GSTP1 isozymes are related with the aneurysms.
The strategy that prevents the oxidative stress for the patients who had aortic aneurysms
could be a valuable choice of searching to effect the aneurysmal progression.
Keywords
aortic aneurysm - aorta/aortic - artery/arteries - coronary bypass surgery - CYP1A1
- GSTP1 - vascular disease
