Ergebnisse einer S2k-Konsensuskonferenz der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselerkrankungen (DGVS) gemeinsam mit der Deutschen Zöliakie-Gesellschaft (DZG) zur Zöliakie, Weizenallergie und Weizensensitivität

Schlüsselwörter

Sprue - Nahrungsmittelintoleranz - Malabsorption - kollagene Kolitis

Key words

sprue - food intolerance - malabsorption - collagenous colitis

^* Gleichberechtigte durch die DGVS mandatierte Koordinatoren der Leitlinie.

• Literatur

• 1 Riddle MS, Murray JA, Porter CK. The incidence and risk of celiac disease in a healthy US adult population. The American journal of gastroenterology 2012; 107: 1248-1255 DOI: 10.1038/ajg.2012.130.
• 2 White LE et al. The rising incidence of celiac disease in Scotland. Pediatrics 2013; 132: e924-e931 DOI: 10.1542/peds.2013-0932.
• 3 Ress K, Luts K, Rago T et al. Nationwide study of childhood celiac disease incidence over a 35-year period in Estonia. European journal of pediatrics 2012; 171: 1823-1828 DOI: 10.1007/s00431-012-1835-0.
• 4 Ludvigsson JF et al. Increasing incidence of celiac disease in a North American population. The American journal of gastroenterology 2013; 108: 818-824 DOI: 10.1038/ajg.2013.60.
• 5 Zanoni G et al. In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. PLoS medicine 2006; 3: e358 DOI: 10.1371/journal.pmed.0030358.
• 6 Ivarsson A, Hernell O, Stenlund H et al. Breast-feeding protects against celiac disease. The American journal of clinical nutrition 2002; 75: 914-921
• 7 Stordal K, White RA, Eggesbo M. Early feeding and risk of celiac disease in a prospective birth cohort. Pediatrics 2013; 132: e1202-1209 DOI: 10.1542/peds.2013-1752.
• 8 Wingren CJ et al. Coeliac disease in children: a social epidemiological study in Sweden. Acta paediatrica 2012 (Oslo, Norway: 1992) 101: 185-191 DOI: 10.1111/j.1651-2227.2011.02434.x.
• 9 Olen O, Bihagen E, Rasmussen F et al. Socioeconomic position and education in patients with coeliac disease. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012; 44: 471-476 DOI: 10.1016/j.dld.2012.01.006.
• 10 Kratzer W et al. Prevalence of celiac disease in Germany: a prospective follow-up study. World journal of gastroenterology 2013; WJG 19: 2612-2620
• 11 Aziz I et al. A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. Eur J Gastroenterol Hepatol 2014; 26: 33-39
• 12 Cosnes J et al. Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2008; 6: 753-758 DOI: 10.1016/j.cgh.2007.12.022.
• 13 Husby S et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. Journal of pediatric gastroenterology and nutrition 2012; 54: 136-160 DOI: 10.1097/MPG.0b013e31821a23d0.
• 14 Rubio-Tapia A, Hill ID, Kelly CP et al. ACG clinical guidelines: diagnosis and management of celiac disease. The American journal of gastroenterology 2013; 108: 656-676 quiz 677 DOI: doi:10.1038/ajg.2013.79.
• 15 Bai JC et al. World Gastroenterology Organisation global guidelines on celiac disease. Journal of clinical gastroenterology 2013; 47: 121-126 DOI: 10.1097/MCG.0b013e31827a6f83.
• 16 Lieb KKD, Koch K, Baethge C et al. Interessenskonflikte in der Medizin: Mit Transparenz Vertrauen stärken. Dtsch Arztebl 2011; 108 (06) A256-A260
• 17 Ludvigsson JF et al. The Oslo definitions for coeliac disease and related terms. Gut 2013; 62: 43-52 DOI: 10.1136/gutjnl-2011-301346.
• 18 Mehta G, Taslaq S, Littleford S et al. The changing face of coeliac disease. British journal of hospital medicine (London, England: 2005) 2008; 69: 84-87
• 19 Zawahir S, Safta A, Fasano A. Pediatric celiac disease. Current opinion in pediatrics 2009; 21: 655-660 DOI: 10.1097/MOP.0b013e32832f5b9d.
• 20 Fasano A. Celiac disease: the past, the present, the future. Pediatrics 2001; 107: 768-770
• 21 Reilly NR et al. Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. Journal of pediatric gastroenterology and nutrition 2011; 53: 528-531 DOI: 10.1097/MPG.0b013e3182276d5e.
• 22 Corazza GR et al. Subclinical celiac sprue. Increasing occurrence and clues to its diagnosis. Journal of clinical gastroenterology 1993; 16: 16-21
• 23 Bottaro G, Cataldo F, Rotolo N et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. The American journal of gastroenterology 1999; 94: 691-696 DOI: 10.1111/j.1572-0241.1999.00938.x.
• 24 Meloni G, Dore A, Fanciulli G et al. Subclinical coeliac disease in schoolchildren from northern Sardinia. Lancet 1999; 353: 37 DOI: 10.1016/s0140-6736(05)74871-6.
• 25 Lebwohl B et al. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study. Annals of internal medicine 2013; 159: 169-175 DOI: 10.7326/0003-4819-159-3-201308060-00006.
• 26 Marine M et al. Impact of mass screening for gluten-sensitive enteropathy in working population. World journal of gastroenterology 2009; 15: 1331-1338
• 27 Rosen A et al. Balancing health benefits and social sacrifices: a qualitative study of how screening-detected celiac disease impacts adolescents' quality of life. BMC pediatrics 2011; 11: 32 DOI: 10.1186/1471-2431-11-32.
• 28 Nordyke K et al. Health-related quality-of-life in children with coeliac disease, measured prior to receiving their diagnosis through screening. Journal of medical screening 2011; 18: 187-192 DOI: 10.1258/jms.2011.011081.
• 29 Vilppula A et al. Clinical benefit of gluten-free diet in screen-detected older celiac disease patients. BMC gastroenterology 2011; 11: 136 DOI: 10.1186/1471-230x-11-136.
• 30 Paavola A et al. Gastrointestinal symptoms and quality of life in screen-detected celiac disease. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012; 44: 814-818 DOI: 10.1016/j.dld.2012.04.019.
• 31 Aziz I, Sanders DS. Are we diagnosing too many people with coeliac disease?. The Proceedings of the Nutrition Society 2012; 71: 538-544 DOI: 10.1017/s0029665112000262.
• 32 Nordyke K et al. Health-related quality of life in adolescents with screening-detected celiac disease, before and one year after diagnosis and initiation of gluten-free diet, a prospective nested case-referent study. BMC public health 2013; 13: 142 DOI: 10.1186/1471-2458-13-142.
• 33 Biagi F et al. Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease?. Journal of clinical pathology 2004; 57: 835-839 DOI: 10.1136/jcp.2003.013607.
• 34 Biagi F et al. Prevalence and natural history of potential celiac disease in adult patients. Scandinavian journal of gastroenterology 2013; 48: 537-542 DOI: 10.3109/00365521.2013.777470.
• 35 Inomata N. Wheat allergy. Current opinion in allergy and clinical immunology 2009; 9: 238-243 DOI: 10.1097/ACI.0b013e32832aa5bc.
• 36 Junker Y et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. The Journal of experimental medicine 2012; 209: 2395-2408 DOI: 10.1084/jem.20102660.
• 37 Biesiekierski JR et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013; 145: 320-328 e321–e323 DOI: 10.1053/j.gastro.2013.04.051.
• 38 Ford RP. The gluten syndrome: a neurological disease. Medical hypotheses 2009; 73: 438-440 DOI: 10.1016/j.mehy.2009.03.037.
• 39 Lundin KE, Alaedini A. Non-celiac gluten sensitivity. Gastrointestinal endoscopy clinics of North America 2012; 22: 723-734 DOI: 10.1016/j.giec.2012.07.006.
• 40 Ukkola A et al. Changes in body mass index on a gluten-free diet in coeliac disease: a nationwide study. European journal of internal medicine 2012; 23: 384-388 DOI: 10.1016/j.ejim.2011.12.012.
• 41 Choi JM et al. Increased prevalence of celiac disease in patients with unexplained infertility in the United States. The Journal of reproductive medicine 2011; 56: 199-203
• 42 Tata LJ et al. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology 2005; 128: 849-855
• 43 Ludvigsson JF, Montgomery SM, Ekbom A. Celiac disease and risk of adverse fetal outcome: a population-based cohort study. Gastroenterology 2005; 129: 454-463 DOI: 10.1016/j.gastro.2005.05.065.
• 44 Ludvigsson JF, Montgomery SM, Ekbom A. Coeliac disease in the father and risk of adverse pregnancy outcome: a population-based cohort study. Scandinavian journal of gastroenterology 2006; 41: 178-185 DOI: 10.1080/00365520510024124.
• 45 Koletzko S. Prevalence of coeliac disease in diabetic children and adolescents. A multicentre study. European journal of pediatrics 1988; 148: 113-117
• 46 Larsson K et al. Annual screening detects celiac disease in children with type 1 diabetes. Pediatric diabetes 2008; 9: 354-359 DOI: 10.1111/j.1399-5448.2008.00367.x.
• 47 Ch'ng CL, Jones MK, Kingham JG. Celiac disease and autoimmune thyroid disease. Clinical medicine & research 2007; 5: 184-192 DOI: 10.3121/cmr.2007.738.
• 48 Drastich P et al. Celiac disease markers in patients with liver diseases: a single center large scale screening study. World journal of gastroenterology 2012; 18: 6255-6262 DOI: 10.3748/wjg.v18.i43.6255.
• 49 Luft LM, Barr SG, Martin LO et al. Autoantibodies to tissue transglutaminase in Sjogren's syndrome and related rheumatic diseases. The Journal of rheumatology 2003; 30: 2613-2619
• 50 Iltanen S et al. Celiac disease and markers of celiac disease latency in patients with primary Sjogren's syndrome. The American journal of gastroenterology 1999; 94: 1042-1046 DOI: 10.1111/j.1572-0241.1999.01011.x.
• 51 Elfstrom P, Montgomery SM, Kampe O et al. Risk of primary adrenal insufficiency in patients with celiac disease. The Journal of clinical endocrinology and metabolism 2007; 92: 3595-3598 DOI: 10.1210/jc.2007-0960.
• 52 Roche Herrero MC et al. The prevalence of headache in a population of patients with coeliac disease. Revista de neurologia 2001; 32: 301-309
• 53 Dimitrova AK et al. Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache 2013; 53: 344-355 DOI: doi:10.1111/j.1526-4610.2012.02260.x.
• 54 Ludvigsson JF, Zingone F, Tomson T et al. Increased risk of epilepsy in biopsy-verified celiac disease: a population-based cohort study. Neurology 2012; 78: 1401-1407 DOI: 10.1212/WNL.0b013e3182544728.
• 55 Smith DF, Gerdes LU. Meta-analysis on anxiety and depression in adult celiac disease. Acta psychiatrica Scandinavica 2012; 125: 189-193 DOI: 10.1111/j.1600-0447.2011.01795.x.
• 56 Hauser W, Janke KH, Klump B et al. Anxiety and depression in adult patients with celiac disease on a gluten-free diet. World journal of gastroenterology 2010; 16: 2780-2787
• 57 Sticherling M, Erfurt-Berge C. Autoimmune blistering diseases of the skin. Autoimmunity reviews 2012; 11: 226-230 DOI: 10.1016/j.autrev.2011.05.017.
• 58 Ludvigsson JF, Lindelof B, Zingone F et al. Psoriasis in a nationwide cohort study of patients with celiac disease. The Journal of investigative dermatology 2011; 131: 2010-2016 DOI: 10.1038/jid.2011.162.
• 59 George EK et al. High frequency of celiac disease in Down syndrome. The Journal of pediatrics 1996; 128: 555-557
• 60 Gale L, Wimalaratna H, Brotodiharjo A et al. Down's syndrome is strongly associated with coeliac disease. Gut 1997; 40: 492-496
• 61 Bonamico M et al. Prevalence and clinical picture of celiac disease in Turner syndrome. The Journal of clinical endocrinology and metabolism 2002; 87: 5495-5498
• 62 Ludvigsson JF, Hemminki K, Wahlstrom J et al. Celiac disease confers a 1.6-fold increased risk of asthma: a nationwide population-based cohort study. The Journal of allergy and clinical immunology 2011; 127: 1071-1073 DOI: 10.1016/j.jaci.2010.12.1076.
• 63 Rubio-Tapia A, Murray JA. The liver in celiac disease. Hepatology (Baltimore, Md.) 2007; 46: 1650-1658 DOI: 10.1002/hep.21949.
• 64 Sainsbury A, Sanders DS, Ford AC. Meta-analysis: Coeliac disease and hypertransaminasaemia. Alimentary pharmacology & therapeutics 2001; 34: 33-40 DOI: 10.1111/j.1365-2036.2011.04685.x.
• 65 Kaukinen K et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology 2002; 122: 881-888
• 66 Cataldo F, Marino V, Bottaro G et al. Celiac disease and selective immunoglobulin A deficiency. The Journal of pediatrics 1997; 131: 306-308
• 67 Heneghan MA, Stevens FM, Cryan EM et al. Celiac sprue and immunodeficiency states: a 25-year review. Journal of clinical gastroenterology 1997; 25: 421-425
• 68 Taubman B, Mamula P, Sherry DD. Prevalence of asymptomatic celiac disease in children with fibromyalgia: a pilot study. Pediatric rheumatology online journal 2011; 9: 11 DOI: 10.1186/1546-0096-9-11.
• 69 Walters JR, Banks LM, Butcher GP et al. Detection of low bone mineral density by dual energy × ray absorptiometry in unsuspected suboptimally treated coeliac disease. Gut 1995; 37: 220-224
• 70 Thorn M et al. Microscopic colitis in Uppsala health region, a population-based prospective study 2005-2009. Scandinavian journal of gastroenterology 2013; 48: 825-830 DOI: 10.3109/00365521.2013.800993.
• 71 Ford AC et al. Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis. Archives of internal medicine 2009; 169: 651-658 DOI: 10.1001/archinternmed.2009.22.
• 72 Card TR, Siffledeen J, West J et al. An excess of prior irritable bowel syndrome diagnoses or treatments in Celiac disease: evidence of diagnostic delay. Scandinavian journal of gastroenterology 2013; 48: 801-807 DOI: 10.3109/00365521.2013.786130.
• 73 Catassi C et al. Risk of non-Hodgkin lymphoma in celiac disease. Journal of the American Medical Association 2002; 287: 1413-1419
• 74 Askling J et al. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 2002; 123: 1428-1435
• 75 Smedby KE et al. Malignant lymphomas in coeliac disease: evidence of increased risks for lymphoma types other than enteropathy-type T cell lymphoma. Gut 2005; 54: 54-59 DOI: 10.1136/gut.2003.032094.
• 76 Elfstrom P et al. Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. Journal of the National Cancer Institute 2011; 103: 436-444 DOI: 10.1093/jnci/djq564.
• 77 Catassi C et al. Detection of Celiac disease in primary care: a multicenter case-finding study in North America. The American journal of gastroenterology 2007; 102: 1454-1460 DOI: 10.1111/j.1572-0241.2007.01173.x.
• 78 Denham JM, Hill ID. Celiac disease and autoimmunity: review and controversies. Current allergy and asthma reports 2013; 13: 347-353 DOI: 10.1007/s11882-013-0352-1.
• 79 Camarca ME et al. Celiac disease in type 1 diabetes mellitus. Italian journal of pediatrics 2012; 38: 10 DOI: 10.1186/1824-7288-38-10.
• 80 Iqbal T, Zaidi MA, Wells GA et al. Celiac disease arthropathy and autoimmunity study. Journal of gastroenterology and hepatology 2013; 28: 99-105 DOI: 10.1111/j.1440-1746.2012.07272.x.
• 81 Cooke WT, Smith WT. Neurological disorders associated with adult coeliac disease. Brain: a journal of neurology 1966; 89: 683-722
• 82 Cash BD et al. The prevalence of celiac disease among patients with nonconstipated irritable bowel syndrome is similar to controls. Gastroenterology 2011; 141: 1187-1193 DOI: 10.1053/j.gastro.2011.06.084.
• 83 Mohseninejad L, Feenstra T, van der Horst HE et al. Targeted screening for Coeliac Disease among irritable bowel syndrome patients: analysis of cost-effectiveness and value of information. The European journal of health economics: HEPAC: health economics in prevention and care 2013; 14: 947-957 DOI: 10.1007/s10198-012-0441-4.
• 84 Green PH et al. Risk of malignancy in patients with celiac disease. The American journal of medicine 2003; 115: 191-195
• 85 Casella G et al. Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010; 42: 175-178 DOI: 10.1016/j.dld.2009.08.005.
• 86 Pereyra L et al. Risk of colorectal neoplasia in patients with celiac disease: A multicenter study. J Crohns Colitis 2013; 7: e672-e677
• 87 Zipser RD, Patel S, Yahya KZ et al. Presentations of adult celiac disease in a nationwide patient support group. Digestive diseases and sciences 2003; 48: 761-764
• 88 Kabbani TA et al. Patients with celiac disease have a lower prevalence of non-insulin-dependent diabetes mellitus and metabolic syndrome. Gastroenterology 2013; 144: 912-917 e911 DOI: 10.1053/j.gastro.2013.01.033.
• 89 Sardy M, Karpati S, Merkl B et al. Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. The Journal of experimental medicine 2002; 195: 747-757
• 90 Donaldson MR et al. Epidermal transglutaminase deposits in perilesional and uninvolved skin in patients with dermatitis herpetiformis. The Journal of investigative dermatology 2007; 127: 1268-1271 DOI: 10.1038/sj.jid.5700682.
• 91 Giersiepen K et al. Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report. Journal of pediatric gastroenterology and nutrition 2012; 54: 229-241 DOI: 10.1097/MPG.0b013e318216f2e5.
• 92 Leffler DA, Schuppan D. Update on serologic testing in celiac disease. The American journal of gastroenterology 2010; 105: 2520-2524 DOI: 10.1038/ajg.2010.276.
• 93 Kurppa K et al. Endomysial antibodies predict celiac disease irrespective of the titers or clinical presentation. World journal of gastroenterology 2012; 18: 2511-2516 DOI: 10.3748/wjg.v18.i20.2511.
• 94 Katz KD et al. Screening for celiac disease in a North American population: sequential serology and gastrointestinal symptoms. The American journal of gastroenterology 2011; 106: 1333-1339 DOI: 10.1038/ajg.2011.21.
• 95 Panetta F et al. Clinical accuracy of anti-tissue transglutaminase as screening test for celiac disease under 2 years. Acta paediatrica (Oslo, Norway: 1992) 2011; 100: 728-731 DOI: 10.1111/j.1651-2227.2010.02124.x.
• 96 Hojsak I et al. Celiac disease screening assays for children younger than 3 years of age: the performance of three serological tests. Digestive diseases and sciences 2012; 57: 127-132 DOI: 10.1007/s10620-011-1857-x.
• 97 Rashtak S, Ettore MW, Homburger HA et al. Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2008; 6: 426-432 quiz 370 DOI: 10.1016/j.cgh.2007.12.030.
• 98 Prause C et al. Antibodies against deamidated gliadin as new and accurate biomarkers of childhood coeliac disease. Journal of pediatric gastroenterology and nutrition 2009; 49: 52-58 DOI: 10.1097/MPG.0b013e318195dae3.
• 99 Niveloni S et al. Antibodies against synthetic deamidated gliadin peptides as predictors of celiac disease: prospective assessment in an adult population with a high pretest probability of disease. Clinical chemistry 2007; 53: 2186-2192 DOI: 10.1373/clinchem.2006.081364.
• 100 McGowan KE, Lyon ME, Butzner JD. Celiac disease and IgA deficiency: complications of serological testing approaches encountered in the clinic. Clinical chemistry 2008; 54: 1203-1209
• 101 Villalta D et al. IgG antibodies against deamidated gliadin peptides for diagnosis of celiac disease in patients with IgA deficiency. Clinical chemistry 2010; 56: 464-468 DOI: 10.1373/clinchem.2009.128132.
• 102 Kappler M, Krauss-Etschmann S, Diehl V et al. Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study. BMJ (Clinical research ed.) 2006; 332: 213-214 DOI: 10.1136/bmj.38688.654028.AE.
• 103 Hogen Esch CE et al. Specific celiac disease antibodies in children on a gluten-free diet. Pediatrics 2011; 128: 547-552 DOI: 10.1542/peds.2010-3762.
• 104 Leffler D et al. Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease. Gut 2013; 62: 996-1004 DOI: 10.1136/gutjnl-2012-302196.
• 105 Fasano A et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Archives of internal medicine. 2003; 163: 286-292
• 106 Goldberg D, Kryszak D, Fasano A et al. Screening for celiac disease in family members: is follow-up testing necessary? Digestive diseases and sciences. 2007; 52: 1082-1086 DOI: 10.1007/s10620-006-9518-1.
• 107 Bybrant MC, Ortqvist E, Lantz S et al. High prevalence of celiac disease in Swedish children and adolescents with type 1 diabetes and the relation to the Swedish epidemic of celiac disease: a cohort study. Scand J Gastroenterol 2014; 49: 52-58
• 108 Leeds JS, Hopper AD, Hadjivassiliou M et al. High prevalence of microvascular complications in adults with type 1 diabetes and newly diagnosed celiac disease. Diabetes care 2011; 34: 2158-2163 DOI: 10.2337/dc11-0149.
• 109 Abid N, McGlone O, Cardwell C et al. Clinical and metabolic effects of gluten free diet in children with type 1 diabetes and coeliac disease. Pediatric diabetes 2011; 12: 322-325 DOI: 10.1111/j.1399-5448.2010.00700.x.
• 110 Lionetti E et al. Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth. The Journal of pediatrics 2012; 161: 908-914 DOI: 10.1016/j.jpeds.2012.05.008.
• 111 Rubio-Tapia A et al. Predictors of family risk for celiac disease: a population-based study. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2008; 6: 983-987 DOI: 10.1016/j.cgh.2008.04.008.
• 112 Kinos S et al. Burden of illness in screen-detected children with celiac disease and their families. Journal of pediatric gastroenterology and nutrition 2012; 55: 412-416 DOI: 10.1097/MPG.0b013e31825f18ff.
• 113 Biagi F et al. The incidence of coeliac disease in adult first degree relatives. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2008; 40: 97-100 DOI: 10.1016/j.dld.2007.10.004.
• 114 Megiorni F et al. HLA-DQ and risk gradient for celiac disease. Human immunology 2009; 70: 55-59 DOI: 10.1016/j.humimm.2008.10.018.
• 115 Karell K et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Human immunology 2003; 64: 469-477
• 116 Vecsei A et al. Influence of age and genetic risk on anti-tissue transglutaminase IgA titers. Journal of pediatric gastroenterology and nutrition 2009; 48: 544-549 DOI: 10.1097/MPG.0b013e31818c5ff6.
• 117 Vivas S et al. Duodenal biopsy may be avoided when high transglutaminase antibody titers are present. World journal of gastroenterology 2009; 15: 4775-4780
• 118 Clouzeau-Girard H et al. HLA-DQ genotyping combined with serological markers for the diagnosis of celiac disease: is intestinal biopsy still mandatory?. Journal of pediatric gastroenterology and nutrition 2011; 52: 729-733 DOI: 10.1097/MPG.0b013e31820a724d.
• 119 Klapp G et al. Celiac disease: the new proposed ESPGHAN diagnostic criteria do work well in a selected population. Journal of pediatric gastroenterology and nutrition 2013; 56: 251-256 DOI: 10.1097/MPG.0b013e318279887b.
• 120 Kurppa K et al. Utility of the new ESPGHAN criteria for the diagnosis of celiac disease in at-risk groups. Journal of pediatric gastroenterology and nutrition 2012; 54: 387-391 DOI: 10.1097/MPG.0b013e3182407c6b.
• 121 Hill PG, Holmes GK. Coeliac disease: a biopsy is not always necessary for diagnosis. Alimentary pharmacology & therapeutics 2008; 27: 572-577 DOI: 10.1111/j.1365-2036.2008.03609.x.
• 122 Dahlbom I et al. Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase. Journal of pediatric gastroenterology and nutrition 2010; 50: 140-146 DOI: 10.1097/MPG.0b013e3181a81384.
• 123 Zanini B et al. High tissue-transglutaminase antibody level predicts small intestinal villous atrophy in adult patients at high risk of celiac disease. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012; 44: 280-285 DOI: 10.1016/j.dld.2011.10.013.
• 124 Fasano A, Catassi C. Clinical practice. Celiac disease. The New England journal of medicine 2012; 367: 2419-2426 DOI: 10.1056/NEJMcp1113994.
• 125 Tosco A et al. Natural history of potential celiac disease in children. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2011; 9: 320-325 quiz e336 DOI: 10.1016/j.cgh.2010.09.006.
• 126 Harper JW, Holleran SF, Ramakrishnan R et al. Anemia in celiac disease is multifactorial in etiology. American journal of hematology 2007; 82: 996-1000 DOI: 10.1002/ajh.20996.
• 127 Garcia-Manzanares A, Lucendo AJ. Nutritional and dietary aspects of celiac disease. Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition 2011; 26: 163-173 DOI: 10.1177/0884533611399773.
• 128 Casella S et al. Celiac disease in elderly adults: clinical, serological, and histological characteristics and the effect of a gluten-free diet. Journal of the American Geriatrics Society 2012; 60: 1064-1069 DOI: 10.1111/j.1532-5415.2012.03997.x.
• 129 Garcia-Manzanares A, Tenias JM, Lucendo AJ. Bone mineral density directly correlates with duodenal Marsh stage in newly diagnosed adult celiac patients. Scandinavian journal of gastroenterology 2012; 47: 927-936 DOI: 10.3109/00365521.2012.688217.
• 130 Cassio A et al. Long-term clinical significance of thyroid autoimmunity in children with celiac disease. The Journal of pediatrics 2010; 156: 292-295 DOI: 10.1016/j.jpeds.2009.08.047.
• 131 Diamanti A et al. Thyroid autoimmunity in children with coeliac disease: a prospective survey. Archives of disease in childhood 2011; 96: 1038-1041 DOI: 10.1136/archdischild-2011-300595.
• 132 Barret M et al. Diagnostic yield of capsule endoscopy in refractory celiac disease. The American journal of gastroenterology 2012; 107: 1546-1553 DOI: 10.1038/ajg.2012.199.
• 133 Kurien M et al. Capsule endoscopy in adult celiac disease: a potential role in equivocal cases of celiac disease?. Gastrointestinal endoscopy 2013; 77: 227-232 DOI: 10.1016/j.gie.2012.09.031.
• 134 Rokkas T, Niv Y. The role of video capsule endoscopy in the diagnosis of celiac disease: a meta-analysis. European journal of gastroenterology & hepatology 2012; 24: 303-308 DOI: 10.1097/MEG.0b013e32834fa914.
• 135 Wolters VM et al. Is gluten challenge really necessary for the diagnosis of coeliac disease in children younger than age 2 years?. Journal of pediatric gastroenterology and nutrition 2009; 48: 566-570 DOI: 10.1097/MPG.0b013e31818c526b.
• 136 Boyce JA et al. Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. The Journal of allergy and clinical immunology 2010; 126: 1105-1118 DOI: 10.1016/j.jaci.2010.10.008.
• 137 Biesiekierski JR et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. The American journal of gastroenterology 2011; 106: 508-514 quiz 515 DOI: 10.1038/ajg.2010.487.
• 138 Carroccio A et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. The American journal of gastroenterology 2012; 107: 1898-1906 quiz 1907 DOI: 10.1038/ajg.2012.236.
• 139 Tuire I et al. Persistent duodenal intraepithelial lymphocytosis despite a long-term strict gluten-free diet in celiac disease. The American journal of gastroenterology 2012; 107: 1563-1569 DOI: 10.1038/ajg.2012.220.
• 140 Taavela J et al. Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2013; 11: 166-171 e161 DOI: 10.1016/j.cgh.2012.09.030.
• 141 Yachha SK et al. Effect of a gluten-free diet on growth and small-bowel histology in children with celiac disease in India. Journal of gastroenterology and hepatology 2007; 22: 1300-1305 DOI: 10.1111/j.1440-1746.2007.04929.x.
• 142 Aydogdu S et al. Long-term effect of gluten-free diet on growth velocity in Turkish children with celiac disease. Digestive diseases and sciences 2009; 54: 2183-2187 DOI: 10.1007/s10620-008-0596-0.
• 143 Weiss B et al. Is adult height of patients with celiac disease influenced by delayed diagnosis? The American journal of gastroenterology. 2008; 103: 1770-1774 DOI: 10.1111/j.1572-0241.2008.01844.x.
• 144 Artz E, Warren-Ulanch J, Becker D et al. Seropositivity to celiac antigens in asymptomatic children with type 1 diabetes mellitus: association with weight, height, and bone mineralization. Pediatric diabetes 2008; 9: 277-284 DOI: 10.1111/j.1399-5448.2008.00386.x.
• 145 Clinical utility of serologic testing for celiac disease in asymptomatic patients: an evidence-based analysis. Ontario health technology assessment series 2001; 11: 1-63
• 146 Bettendorf M et al. Prevalence of autoantibodies associated with thyroid and celiac disease in Ullrich-Turner syndrome in relation to adult height after growth hormone treatment. Journal of pediatric endocrinology & metabolism 2006; 19: 149-154
• 147 Khashan AS et al. The impact of maternal celiac disease on birthweight and preterm birth: a Danish population-based cohort study. Human reproduction (Oxford, England) 2010; 25: 528-534 DOI: 10.1093/humrep/dep409.
• 148 Kumar A et al. Latent celiac disease in reproductive performance of women. Fertility and sterility 2011; 95: 922-927 DOI: 10.1016/j.fertnstert.2010.11.005.
• 149 Ozgor B, Selimoglu MA. Coeliac disease and reproductive disorders. Scandinavian journal of gastroenterology 2010; 45: 395-402 DOI: 10.3109/00365520903508902.
• 150 Matysiak-Budnik T et al. Long-term follow-up of 61 coeliac patients diagnosed in childhood: evolution toward latency is possible on a normal diet. Gut 2007; 56: 1379-1386 DOI: 10.1136/gut.2006.100511.
• 151 Hopman EG et al. Gluten tolerance in adult patients with celiac disease 20 years after diagnosis?. European journal of gastroenterology & hepatology 2008; 20: 423-429 DOI: 10.1097/MEG.0b013e3282f4de6e.
• 152 Koerner TB et al. Gluten contamination of naturally gluten-free flours and starches used by Canadians with celiac disease. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2013; 30: 2017-2021
• 153 Catassi C et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. The American journal of clinical nutrition 2007; 85: 160-166
• 154 Akobeng AK, Thomas AG. Systematic review: tolerable amount of gluten for people with coeliac disease. Alimentary pharmacology & therapeutics 2008; 27: 1044-1052 DOI: 10.1111/j.1365-2036.2008.03669.x.
• 155 Hollon JR, Cureton PA, Martin ML et al. Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients. BMC gastroenterology 2013; 13: 40 DOI: 10.1186/1471-230x-13-40.
• 156 Sollid LM, Qiao SW, Anderson RP et al. Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules. Immunogenetics 2012; 64: 455-460 DOI: 10.1007/s00251-012-0599-z.
• 157 Thompson T. Gluten contamination of commercial oat products in the United States. The New England journal of medicine 2004; 351: 2021-2022 DOI: 10.1056/nejm200411043511924.
• 158 Koerner TB et al. Gluten contamination in the Canadian commercial oat supply. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2011; 28: 705-710
• 159 Sey MS, Parfitt J, Gregor J. Prospective study of clinical and histological safety of pure and uncontaminated Canadian oats in the management of celiac disease. JPEN. Journal of parenteral and enteral nutrition 2011; 35: 459-464 DOI: 10.1177/0148607110387800.
• 160 Haboubi NY, Taylor S, Jones S. Coeliac disease and oats: a systematic review. Postgraduate medical journal 2006; 82: 672-678 DOI: 10.1136/pgmj.2006.045443.
• 161 Pulido OM et al. Introduction of oats in the diet of individuals with celiac disease: a systematic review. Advances in food and nutrition research 2009; 57: 235-285 DOI: 10.1016/s1043-4526(09)57006-4.
• 162 Garsed K, Scott BB. Can oats be taken in a gluten-free diet? A systematic review. Scandinavian journal of gastroenterology 2007; 42: 171-178 DOI: 10.1080/00365520600863944.
• 163 Koskinen O et al. Oats do not induce systemic or mucosal autoantibody response in children with coeliac disease. Journal of pediatric gastroenterology and nutrition 2009; 48: 559-565 DOI: 10.1097/MPG.0b013e3181668635.
• 164 Mattar R, de Campos Mazo DF, Carrilho FJ. Lactose intolerance: diagnosis, genetic, and clinical factors. Clinical and experimental gastroenterology 2012; 5: 113-121 DOI: 10.2147/ceg.s32368.
• 165 Raithel M et al. Kohlenhydratmalassimilation häufig vorkommender Mono- und Disaccharide: Abgestuftes diagnostisches Vorgehen und Differenzialdiagnosen. Dtsch Arztebl 2013; 110: 775-782
• 166 Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M et al. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 2013; 5: 3975-3992 DOI: 10.3390/nu5103975.
• 167 Abu DayaH, Lebwohl B, Lewis SK et al. Celiac disease patients presenting with anemia have more severe disease than those presenting with diarrhea. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2013; 11: 1472-1477 DOI: 10.1016/j.cgh.2013.05.030.
• 168 Annibale B et al. Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients. The American journal of gastroenterology 2001; 96: 132-137 DOI: 10.1111/j.1572-0241.2001.03463.x.
• 169 Lucendo AJ, Garcia-Manzanares A. Bone mineral density in adult coeliac disease: An updated review. Revista espanola de enfermedades digestivas: organo oficial de la Sociedad Espanola de Patologia Digestiva 2013; 105: 154-162
• 170 Szymczak J, Bohdanowicz-Pawlak A, Waszczuk E et al. Low bone mineral density in adult patients with coeliac disease. Endokrynologia Polska 2012; 63: 270-276
• 171 Passananti V et al. Bone mass in women with celiac disease: role of exercise and gluten-free diet. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2012; 44: 379-383 DOI: 10.1016/j.dld.2011.12.012.
• 172 V CDO. e. DVO-Leitlinie 2009 zur Prophylaxe, Diagnostik und Therapie der Osteoporose bei Erwachsenen. Langfassung. Osteologie 2009; 18: 304-328
• 173 Shepherd SJ, Gibson PR. Nutritional inadequacies of the gluten-free diet in both recently-diagnosed and long-term patients with coeliac disease. Journal of human nutrition and dietetics: the official journal of the British Dietetic Association 2013; 26: 349-358 DOI: 10.1111/jhn.12018.
• 174 Martin J, Geisel T, Maresch C et al. Inadequate nutrient intake in patients with celiac disease: results from a german dietary survey. Digestion 2013; 87: 240-246 DOI: 10.1159/000348850.
• 175 Wild D, Robins GG, Burley VJ et al. Evidence of high sugar intake, and low fibre and mineral intake, in the gluten-free diet. Alimentary pharmacology & therapeutics 2010; 32: 573-581 DOI: 10.1111/j.1365-2036.2010.04386.x.
• 176 Ohlund K, Olsson CHernell O, Ohlund I. Dietary shortcomings in children on a gluten-free diet. Journal of human nutrition and dietetics: the official journal of the British Dietetic Association 2010; 23: 294-300 DOI: 10.1111/j.1365-277X.2010.01060.x.
• 177 Mozer-Glassberg Y et al. Follow-up of children with celiac disease – lost in translation?. Digestion 2011; 83: 283-287 DOI: 10.1159/000320714.
• 178 Jacobsson LR, Friedrichsen M, Goransson A et al. Impact of an active patient education program on gastrointestinal symptoms in women with celiac disease following a gluten-free diet: a randomized controlled trial. Gastroenterology nursing: the official journal of the Society of Gastroenterology Nurses and Associates 2012; 35: 200-206 DOI: 10.1097/SGA.0b013e318255fe3a.
• 179 Zanini B et al. Five year time course of celiac disease serology during gluten free diet: results of a community based "CD-Watch" program. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010; 42: 865-870 DOI: 10.1016/j.dld.2010.05.009.
• 180 Silvester JA, Rashid M. Long-term follow-up of individuals with celiac disease: an evaluation of current practice guidelines. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2007; 21: 557-564
• 181 Nachman F et al. Serological tests for celiac disease as indicators of long-term compliance with the gluten-free diet. European journal of gastroenterology & hepatology 2011; 23: 473-480 DOI: 10.1097/MEG.0b013e328346e0f1.
• 182 Candon S, Mauvais FX, Garnier-Lengline H et al. Monitoring of anti-transglutaminase autoantibodies in pediatric celiac disease using a sensitive radiobinding assay. Journal of pediatric gastroenterology and nutrition 2012; 54: 392-396 DOI: 10.1097/MPG.0b013e318232c459.
• 183 Aziz I, Evans KE, Papageorgiou V et al. Are patients with coeliac disease seeking alternative therapies to a gluten-free diet?. Journal of gastrointestinal and liver diseases 2011; 20: 27-31
• 184 Kaukinen K, Lindfors K, Maki M. Advances in the treatment of coeliac disease: an immunopathogenic perspective. Nat Rev Gastroenterol Hepatol 2014; 11: 36-44
• 185 Lindfors K et al. Future treatment strategies for celiac disease. Expert opinion on therapeutic targets 2012; 16: 665-675 DOI: 10.1517/14728222.2012.688808.
• 186 Mukherjee R, Kelly CP, Schuppan D. Nondietary therapies for celiac disease. Gastrointestinal endoscopy clinics of North America 2012; 22: 811-831 DOI: 10.1016/j.giec.2012.09.001.
• 187 Szajewska H et al. Systematic review: early infant feeding and the prevention of coeliac disease. Alimentary pharmacology & therapeutics 2012; 36: 607-618 DOI: 10.1111/apt.12023.
• 188 Akobeng AK, Ramanan AV, Buchan I et al. Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies. Archives of disease in childhood 2006; 91: 39-43 DOI: 10.1136/adc.2005.082016.
• 189 Norris JM et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. Journal of the American Medical Association 2005; 293: 2343-2351 DOI: 10.1001/jama.293.19.2343.
• 190 Persson LA, Ivarsson A, Hernell O. Breast-feeding protects against celiac disease in childhood – epidemiological evidence. Advances in experimental medicine and biology 2002; 503: 115-123
• 191 Ivarsson A et al. Prevalence of childhood celiac disease and changes in infant feeding. Pediatrics 2013; 131: e687-694 DOI: 10.1542/peds.2012-1015.
• 192 Hogen Esch CE et al. The PreventCD Study design: towards new strategies for the prevention of coeliac disease. European journal of gastroenterology & hepatology 2010; 22: 1424-1430 DOI: 10.1097/MEG.0b013e32833fe9ae.
• 193 Mehl A et al. The atopy patch test in the diagnostic workup of suspected food-related symptoms in children. The Journal of allergy and clinical immunology 2006; 118: 923-929 DOI: 10.1016/j.jaci.2006.07.003.
• 194 Beyer K et al. The role of wheat omega-5 gliadin IgE antibodies as a diagnostic tool for wheat allergy in childhood. The Journal of allergy and clinical immunology 2008; 122: 419-421 DOI: 10.1016/j.jaci.2008.06.006.
• 195 Hill ID et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Journal of pediatric gastroenterology and nutrition 2005; 40: 1-19
• 196 Branski D, Faber J, Freier S et al. Histologic evaluation of endoscopic versus suction biopsies of small intestinal mucosae in children with and without celiac disease. Journal of pediatric gastroenterology and nutrition 1998; 27: 6-11
• 197 Oderda G et al. Endoscopic and histologic findings in the upper gastrointestinal tract of children with coeliac disease. Journal of pediatric gastroenterology and nutrition 1993; 16: 172-177
• 198 Abdulkarim AS, Burgart LJ, See J et al. Etiology of nonresponsive celiac disease: results of a systematic approach. The American journal of gastroenterology 2002; 97: 2016-2021 DOI: 10.1111/j.1572-0241.2002.05917.x.
• 199 Leffler DA et al. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2007; 5: 445-450 DOI: 10.1016/j.cgh.2006.12.006.
• 200 Mooney PD, Evans KE, Singh S et al. Treatment failure in coeliac disease: a practical guide to investigation and treatment of non-responsive and refractory coeliac disease. Journal of gastrointestinal and liver diseases 2012; 21: 197-203
• 201 Nijeboer P, van Wanrooij RL, Tack GJ et al. Update on the diagnosis and management of refractory coeliac disease. Gastroenterology research and practice 2013; 2013: 518483 DOI: 10.1155/2013/518483.
• 202 Rubio-Tapia A, Murray JA. Classification and management of refractory coeliac disease. Gut 2010; 59: 547-557 DOI: 10.1136/gut.2009.195131.
• 203 Rashid M, MacDonald A. Importance of duodenal bulb biopsies in children for diagnosis of celiac disease in clinical practice. BMC gastroenterology 2009; 9: 78 DOI: 10.1186/1471-230x-9-78.
• 204 Ravelli A et al. How patchy is patchy villous atrophy? distribution pattern of histological lesions in the duodenum of children with celiac disease. The American journal of gastroenterology 2010; 105: 2103-2110 DOI: 10.1038/ajg.2010.153.
• 205 Bonamico M et al. Duodenal bulb biopsies in celiac disease: a multicenter study. Journal of pediatric gastroenterology and nutrition 2008; 47: 618-622
• 206 Green PH, Cellier C. Celiac disease. The New England journal of medicine 2007; 357: 1731-1743 DOI: 10.1056/NEJMra071600.
• 207 Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 2006; 131: 1981-2002 DOI: 10.1053/j.gastro.2006.10.004.
• 208 Lebwohl B, Kapel RC, Neugut AI et al. Adherence to biopsy guidelines increases celiac disease diagnosis. Gastrointestinal endoscopy 2011; 74: 103-109 DOI: 10.1016/j.gie.2011.03.1236.
• 209 Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. European journal of gastroenterology & hepatology 1999; 11: 1185-1194
• 210 Villanacci V, Ceppa P, Tavani E et al. Coeliac disease: the histology report. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2011; 43 (Suppl. 04) S385-S395 DOI: 10.1016/s1590-8658(11)60594-x.
• 211 Pellegrino S et al. Redefining the intraepithelial lymphocytes threshold to diagnose gluten sensitivity in patients with architecturally normal duodenal histology. Alimentary pharmacology & therapeutics 2011; 33: 697-706 DOI: 10.1111/j.1365-2036.2011.04578.x.
• 212 Walker MM et al. Detection of celiac disease and lymphocytic enteropathy by parallel serology and histopathology in a population-based study. Gastroenterology 2010; 139: 112-119 DOI: 10.1053/j.gastro.2010.04.007.
• 213 Dickson BC, Streutker CJ, Chetty R. Coeliac disease: an update for pathologists. Journal of clinical pathology 2006; 59: 1008-1016 DOI: 10.1136/jcp.2005.035345.
• 214 Rubio-Tapia A et al. Clinical staging and survival in refractory celiac disease: a single center experience. Gastroenterology 2009; 136: 99-107 quiz 352-103 DOI: 10.1053/j.gastro.2008.10.013.
• 215 Malamut G et al. Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology 2009; 136: 81-90 DOI: 10.1053/j.gastro.2008.09.069.
• 216 Roshan B et al. The incidence and clinical spectrum of refractory celiac disease in a north american referral center. The American journal of gastroenterology 2011; 106: 923-928 DOI: 10.1038/ajg.2011.104.
• 217 Ashton-Key M, Diss TC, Pan L et al. Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy-associated T-cell lymphoma. The American journal of pathology 1997; 151: 493-498
• 218 Cellier C et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 2000; 356: 203-208
• 219 Patey-Mariaud De Serre N et al. Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method. Histopathology 2000; 37: 70-77
• 220 de Mascarel A et al. Mucosal intraepithelial T-lymphocytes in refractory celiac disease: a neoplastic population with a variable CD8 phenotype. The American journal of surgical pathology 2008; 32: 744-751 DOI: 10.1097/PAS.0b013e318159b478.
• 221 Daum S et al. High rates of complications and substantial mortality in both types of refractory sprue. European journal of gastroenterology & hepatology 2009; 21: 66-70 DOI: 10.1097/MEG.0b013e328307c20c.
• 222 Grainge MJ, West J, Solaymani-Dodaran M et al. The long-term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study. Alimentary pharmacology & therapeutics 2012; 35: 730-739 DOI: 10.1111/j.1365-2036.2012.04998.x.
• 223 Holmes GK et al. Coeliac disease, gluten-free diet, and malignancy. Gut 1976; 17: 612-619
• 224 Al-toma A, Verbeek WH, Mulder CJ. The management of complicated celiac disease. Digestive diseases (Basel, Switzerland) 2007; 25: 230-236 DOI: 10.1159/000103891.
• 225 Daum S et al. Intestinal non-Hodgkin's lymphoma: a multicenter prospective clinical study from the German Study Group on Intestinal non-Hodgkin's Lymphoma. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2003; 21: 2740-2746 DOI: 10.1200/jco.2003.06.026.
• 226 Daum S, Cellier C, Mulder CJ. Refractory coeliac disease. Best practice & research. Clinical gastroenterology 2005; 19: 413-424 DOI: 10.1016/j.bpg.2005.02.001.
• 227 Daum S et al. Frequency of clonal intraepithelial T lymphocyte proliferations in enteropathy-type intestinal T cell lymphoma, coeliac disease, and refractory sprue. Gut 2001; 49: 804-812
• 228 O'Shea U et al. Investigation of molecular markers in the diagnosis of refractory coeliac disease in a large patient cohort. Journal of clinical pathology 2008; 61: 1200-1202 DOI: 10.1136/jcp.2008.058404.
• 229 Delabie J et al. Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project. Blood 2011; 118: 148-155 DOI: 10.1182/blood-2011-02-335216.
• 230 Malamut G et al. Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2013; 45: 377-384 DOI: 10.1016/j.dld.2012.12.001.
• 231 Wahab PJ, Meijer JW, Mulder CJ. Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. American journal of clinical pathology 2002; 118: 459-463 DOI: 10.1309/evxt-851x-whlc-rlx9.
• 232 Verbeek WH et al. Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in Refractory Celiac Disease. Clinical immunology (Orlando, Fla.) 2008; 126: 48-56 DOI: 10.1016/j.clim.2007.09.002.
• 233 Daum S et al. Capsule endoscopy in refractory celiac disease. Endoscopy 2007; 39: 455-458 DOI: 10.1055/s-2007-966239.
• 234 Mallant M et al. Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma. World journal of gastroenterology 2007; 13: 1696-1700
• 235 Van Weyenberg SJ et al. MR enteroclysis in refractory celiac disease: proposal and validation of a severity scoring system. Radiology 2011; 259: 151-161 DOI: 10.1148/radiol.11101808.
• 236 Van Weyenberg SJ, Smits F, Jacobs MA et al. Video capsule endoscopy in patients with nonresponsive celiac disease. Journal of clinical gastroenterology 2013; 47: 393-399 DOI: 10.1097/MCG.0b013e31826bea12.
• 237 Cellier C et al. Push enteroscopy in celiac sprue and refractory sprue. Gastrointestinal endoscopy 1999; 50: 613-617
• 238 Atlas DS, Rubio-Tapia A, Van Dyke CT et al. Capsule endoscopy in nonresponsive celiac disease. Gastrointestinal endoscopy 2011; 74: 1315-1322 DOI: 10.1016/j.gie.2011.05.049.
• 239 Van Weyenberg SJ et al. Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease. Abdominal imaging 2013; 38: 42-51 DOI: 10.1007/s00261-012-9892-4.
• 240 Rettenbacher T, Hollerweger A, Macheiner P et al. Adult celiac disease: US signs. Radiology 1999; 211: 389-394 DOI: 10.1148/radiology.211.2.r99ma39389.
• 241 Hadithi M et al. 18F-FDG PET versus CT for the detection of enteropathy-associated T-cell lymphoma in refractory celiac disease. Journal of nuclear medicine: official publication, Society of Nuclear Medicine 2006; 47: 1622-1627
• 242 Olaussen RW et al. Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac disease. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2005; 3: 875-885
• 243 Brar P et al. Budesonide in the treatment of refractory celiac disease. The American journal of gastroenterology 2007; 102: 2265-2269 DOI: 10.1111/j.1572-0241.2007.01380.x.
• 244 Daum S et al. Therapy with budesonide in patients with refractory sprue. Digestion 2006; 73: 60-68 DOI: 10.1159/000092639.
• 245 Goerres MS et al. Azathioprine and prednisone combination therapy in refractory coeliac disease. Alimentary pharmacology & therapeutics 2003; 18: 487-494
• 246 Tack GJ, van Asseldonk DP, van Wanrooij RL et al. Tioguanine in the treatment of refractory coeliac disease – a single centre experience. Alimentary pharmacology & therapeutics 2012; 36: 274-281 DOI: 10.1111/j.1365-2036.2012.05154.x.
• 247 Gillett HR et al. Successful infliximab treatment for steroid-refractory celiac disease: a case report. Gastroenterology 2002; 122: 800-805
• 248 Daum S et al. Adult autoimmune enteropathy treated successfully with tacrolimus. Digestion 2003; 68: 86-90 DOI: 74520.
• 249 Jamma S et al. Small intestinal release mesalamine for the treatment of refractory celiac disease type I. Journal of clinical gastroenterology 2011; 45: 30-33 DOI: 10.1097/MCG.0b013e3181f42401.
• 250 Al-Toma A et al. Cladribine therapy in refractory celiac disease with aberrant T cells. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2006; 4: 1322-1327 quiz 1300 DOI: 10.1016/j.cgh.2006.07.007.
• 251 Tack GJ et al. Evaluation of Cladribine treatment in refractory celiac disease type II. World journal of gastroenterology 2011; 17: 506-513 DOI: 10.3748/wjg.v17.i4.506.
• 252 Hadjibabaie M et al. Evaluation of nutritional status in patients undergoing hematopoietic SCT. Bone marrow transplantation 2008; 42: 469-473 DOI: 10.1038/bmt.2008.188.
• 253 Verbeek WH, Mulder CJ, Zweegman S. Alemtuzumab for refractory celiac disease. The New England journal of medicine 2006; 355: 1396-1397 author reply 1397 DOI: 10.1056/NEJMc061784.
• 254 Vivas S, Ruiz de Morales JM, Ramos F et al. Alemtuzumab for refractory celiac disease in a patient at risk for enteropathy-associated T-cell lymphoma. The New England journal of medicine 2006; 354: 2514-2515 DOI: 10.1056/NEJMc053129.
• 255 Tack GJ et al. Auto-SCT in refractory celiac disease type II patients unresponsive to cladribine therapy. Bone marrow transplantation 2011; 46: 840-846 DOI: 10.1038/bmt.2010.199.
• 256 Bachle T, Ruhl U, Ott G et al. Enteropathy-associated T-cell lymphoma. Manifestation as diet-refractory coeliac disease and ulcerating jejunitis. Deutsche medizinische Wochenschrift (1946) 2001; 126: 1460-1463 DOI: 10.1055/s-2001-19212.
• 257 Chott A et al. Most CD56+ intestinal lymphomas are CD8+CD5-T-cell lymphomas of monomorphic small to medium size histology. The American journal of pathology 1998; 153: 1483-1490 DOI: 10.1016/s0002-9440(10)65736-7.
• 258 Chan JK et al. Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent gammadelta T-cell receptor expression. The American journal of surgical pathology 2011; 35: 1557-1569 DOI: 10.1097/PAS.0b013e318222dfcd.
• 259 Al-Toma A et al. Disappointing outcome of autologous stem cell transplantation for enteropathy-associated T-cell lymphoma. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2007; 39: 634-641 DOI: 10.1016/j.dld.2007.03.009.
• 260 Raderer M et al. Second line chemotherapy in patients with enteropathy-associated T cell lymphoma: a retrospective single center analysis. Annals of hematology 2012; 91: 57-61 DOI: 10.1007/s00277-011-1236-x.
• 261 Goldberg JD et al. T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation 2013; 19: 208-213 DOI: 10.1016/j.bbmt.2012.09.003.