Int Arch Otorhinolaryngol 2014; 18(03): 239-243
DOI: 10.1055/s-0033-1363466
Original Research
Thieme Publicações Ltda Rio de Janeiro, Brazil

Möbius Syndrome: Misoprostol Use and Speech and Language Characteristics

Zelita Caldeira Ferreira Guedes
1  Department of Speech and Language, Escola Paulista de Medicina at Universidade Federal de São Paulo, São Paulo, SP, Brazil
› Author Affiliations
Further Information

Publication History

13 January 2013

23 August 2013

Publication Date:
21 March 2014 (online)



Introduction Möbius syndrome (MS; VI and VII palsy) is a rare disease that in Brazil has a great frequency because of the use of misoprostol during pregnancy.

Objective Verify if the speech and language performance of children with MS whose mothers reported use of misoprostol (Cytotec, Pfizer, Connecticut, USA) are different from the performance of children of mothers who did not report use.

Methods The stomatognathic system beyond receptive and expressive language and speech was evaluated in children with MS, and their mothers were questioned whether they used misoprostol during the pregnancy.

Results During the interview, 61.11% of mothers reported that they took misoprostol during the pregnancy. Most of the subjects (83.3%) whose mothers took misoprostol presented bilateral palsy beyond bad mobility of the tongue (90.9%) and speech disorders (63.6%).

Conclusion The number of mothers who took misoprostol without knowing the risk for MS was great. The lack of facial expressions and speech disorders were common characteristics of the individuals with MS, whether the mothers took misoprostol during the pregnancy or not.