Neuropediatrics 2014; 45(02): 109-116
DOI: 10.1055/s-0033-1363297
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Retrospective Study of the Investigations of Children Presenting with Lower Limbs Spasticity in a Single Institution

Carlotta Spagnoli
1   Department of Neurology, Great Ormond Street Hospital for Children, London, United Kingdom.
,
Carlos de Sousa
1   Department of Neurology, Great Ormond Street Hospital for Children, London, United Kingdom.
› Institutsangaben
Weitere Informationen

Publikationsverlauf

12. Juli 2013

01. Oktober 2013

Publikationsdatum:
21. Dezember 2013 (online)

Abstract

Objectives This retrospective study was undertaken to identify how children with spasticity entirely or mainly affecting lower limbs are investigated in a single institution, to address the diagnostic yield of these investigations, and to establish an improved diagnostic algorithm.

Methods Clinical documents regarding children referred to our institution for the diagnostic investigation of spastic diplegia and receiving their first clinical appointment between the July 1, 2010, and the December 31, 2010, were identified in our electronic database. Clinical correspondence, case-notes, magnetic resonance imaging reports, and other investigation results were reviewed.

Results For the 26 patients (16 males) identified, there was much variability in the investigations offered. In the 53.84% of them, a specific diagnosis was found, including one case of hereditary spastic paraplegia 3A and one of neuroblastoma.

Conclusions Diagnostic rate could be optimized by a more standardized approach to investigations and by rational genetic testing. A comprehensive diagnostic algorithm is proposed for implementation of etiological diagnosis.

 
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