Amer J Perinatol 2014; 31(09): 773-780
DOI: 10.1055/s-0033-1361831
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Renal Development and Neonatal Adaptation

M. Saint-Faust
1  Department of Neonatology, Universitary Hospital, Nice, France
,
F. Boubred
2  Department of Neonatology, Universitary Hospital, La Conception and Aix-Marseille University, Marseille, France
,
U. Simeoni
2  Department of Neonatology, Universitary Hospital, La Conception and Aix-Marseille University, Marseille, France
› Author Affiliations
Further Information

Publication History

07 December 2012

27 September 2013

Publication Date:
12 March 2014 (eFirst)

Abstract

The structural and functional development of the kidney is responsible for a significant impact on postnatal adaptation to extrauterine life. Prenatal or neonatal impairment of nephrogenesis may carry long term, lifelong consequences in terms of reduced nephron endowment, chronic kidney disease, and cardiovascular risks at adulthood. Intrauterine growth restriction, preterm birth, congenital renal, and urinary tract anomalies are for long widely incriminated. Neonatal administration of nephrotoxic drugs has been associated with short-term acute kidney injury and longer chronic kidney disease. This review attempts at offering a comprehensive understanding of the renal development, the neonatal renal transition to extrauterine life and subsequent maturation phase during early infancy. It also focuses on developmental and maturational changes that impact lifelong renal function and adult health.