Cytomegalovirus infection and CMV-hyper immunoglobulin therapy

GO Ajayi; E Shola

doi:10.1055/s-0033-1361241

Zeitschrift für Geburtshilfe und Neonatologie, Inhaltsverzeichnis

Cytomegalovirus infection and CMV-hyper immunoglobulin therapy

GO Ajayi ¹^,², E Shola ¹

¹College of Medicine of University of Lagos, Prenatal Diagnosis and Therapy Centre, Lagos, Nigeria
²College of Medicine of University of Lagos, Dept. of Obstetrics & Gynaecology, Lagos, Nigeria

Abstract

Introduction: Worldwide 0.5%-20% of all new born is infected with CMV and is the most common congenital infection. Recently, intrauterine therapy with CMV hyper immunoglobulin has been reported.

Case reports: A total of 9 pregnancies have received treatment between 16 and 33 weeks of gestation. 2 cases were primary CMV infections. In all cases, amniocentesis was performed for confirmation. After informed consent obtained, CMV hyper immunoglobulin therapy was given. In three cases, antiviral therapy was used.

Results: Despite therapy, there were 2 intrauterine fetal deaths and 7 were delivered alive and followed up postnatally.

Conclusion: CMV Hyperimmunoglobulin therapy serves to reduce the complication of CMV infection in pregnancies. More reports are needed to support such therapy.