The Inhibitory Effect of Scutellaria baicalensis Extract and
                    Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor
                    with Implications for Preventing Androgenetic Alopecia

Ah-Reum Kim; Su-Na Kim; In-Keun Jung; Hyun-Hee Kim; Young-Ho Park; Won-Seok Park

doi:10.1055/s-0033-1360300

Planta Medica, Inhaltsverzeichnis

Planta Med 2014; 80(02/03): 153-158
DOI: 10.1055/s-0033-1360300

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

The Inhibitory Effect of Scutellaria baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia

Authors

Ah-Reum Kim

¹Advanced Hair Research Laboratory, AMOREPACIFIC Corp. R&D Unit, Gyeonggi Province, South Korea
Su-Na Kim

¹Advanced Hair Research Laboratory, AMOREPACIFIC Corp. R&D Unit, Gyeonggi Province, South Korea
In-Keun Jung

²Analysis Research Team, AMOREPACIFIC Corp. R&D Unit, Gyeonggi Province, South Korea
Hyun-Hee Kim

²Analysis Research Team, AMOREPACIFIC Corp. R&D Unit, Gyeonggi Province, South Korea
Young-Ho Park

³Medical Beauty Research Division, AMOREPACIFIC Corp. R&D Unit, Gyeonggi Province, South Korea
Won-Seok Park

¹Advanced Hair Research Laboratory, AMOREPACIFIC Corp. R&D Unit, Gyeonggi Province, South Korea

Abstract

Androgens affect several human skin and prostate functions, and the androgen receptor is crucial for regulating the androgen-related mechanisms. In this study, we assessed the antagonizing effects of a Scutellaria baicalensis extract and its main component baicalin on proliferation of human scalp dermal papilla cells. First, the extract and baicalin slightly dissociated the radioisotope-labeled androgen receptor-agonist complex in the androgen receptor binding assay, and the IC₅₀ values were measured to assess the androgen receptor antagonistic effect of the extract (93 µg/mL) and baicalin (54.1 µM). Second, the extract and baicalin treatments dose-dependently inhibited the overgrowth of LNCaP prostate cancer cells, which were stimulated by dihydrotestosterone. Third, the extract and baicalin inhibited nuclear translocation of the androgen receptor stimulated by dihydrotestosterone in human dermal papilla cells. Additionally, the extract and baicalin enhanced proliferation of human dermal papilla cells in vitro. These results show that the extract and baicalin inhibited androgen activation signaling and promoted hDPC proliferation, suggesting that they could be used as active ingredients for treating androgen-associated disorders, such as androgenetic alopecia.

Key words

baicalin - Scutellaria baicalensis - Lamiaceae - dihydrotestosterone - androgen receptor - androgen antagonism - androgenetic alopecia

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Referenzen

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