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Planta Med 2014; 80(02/03): 223-230
DOI: 10.1055/s-0033-1360279
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana

Gui-Guang Cheng
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   Graduate School of Chinese Academy of Sciences, Beijing, P. R. China
,
Xiang-Hai Cai
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Bao-Hong Zhang
3   Yunnan University of Traditional Chinese Medicine, Kunming, P. R. China
,
Yan Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Ji Gu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   Graduate School of Chinese Academy of Sciences, Beijing, P. R. China
,
Mei-Fen Bao
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
2   Graduate School of Chinese Academy of Sciences, Beijing, P. R. China
,
Ya-Ping Liu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Xiao-Dong Luo
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› Author Affiliations
Further Information

Publication History

received 28 August 2013
revised 22 October 2013

accepted 16 December 2013

Publication Date:
22 January 2014 (online)

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Abstract

Seven new cinchona alkaloids, cinchonanines A–G (1–7), and 29 known alkaloids were isolated from the barks of Cinchona surrirubra and C. ledgeriana collected from Yunnan Province in China. The new structures were elucidated by extensive spectroscopic analysis. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 2, 13, 14, and 15 showed moderate cytotoxicity.

Key words

Cinchona surrirubra - Cinchona ledgeriana - Rubiaceae - cinchonanines A–G - cinchona alkaloids - cytotoxicity

Supporting Information

 

  • References

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