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DOI: 10.1055/s-0033-1358062
Die roboterassistierte radikale Prostatektomie – Literaturreview zum onkologischen und funktionellen Outcome
Robot-Assisted Radical Prostatectomy – Review of the Literature Concerning Oncological and Functional Outcome of PatientsPublication History
Publication Date:
16 December 2014 (online)
Zusammenfassung
Im Jahr 2000 erfolgte in Frankfurt am Main (Deutschland) die weltweit erste roboterassistierte radikale Prostatektomie (RARP) zur operativen Therapie des Prostatakarzinoms (PCA). Es fand seitdem eine schnelle Verbreitung dieser innovativen Operationsmethode statt. In den USA ist die RARP bereits die am häufigsten durchgeführte Therapieform des lokal begrenzten PCA, obwohl die Vorteile dieser minimal-invasiven Prozedur gegenüber anderen Verfahren bislang nicht anhand einer prospektiv-randomisierten Studie untersucht wurden. Vor dem Hintergrund der auch in Deutschland zu verzeichnenden raschen Zunahme der RARP als primäre Therapie des lokalisierten PCA soll der vorliegende Artikel einen kritischen Überblick über bisher in der internationalen Literatur publizierte onkologische und funktionelle Ergebnisse der RARP bieten. Die Arbeit folgt hierbei dem Ziel, die Sicherheit der RARP hinsichtlich der Erlangung der Pentafecta-Outcome Kriterien (kein PSA-Rezidiv, vollständige Erlangung der Harnkontinenz und Erektionsfähigkeit, negativer chirurgischer Schnittrand und keine postoperativen Komplikationen) zu bewerten, jenen Kriterien, die 2011 von Patel et al. erstmalig beschrieben wurden.
Abstract
In 2000, the first robot-assisted radical prostatectomy (RARP) worldwide for treatment of prostate cancer (PCa) was performed in Frankfurt/Main (Germany). Since then, this surgical method has broadly dispersed. In the US, RARP currently already represents the most frequently applied surgical technique for treatment of localized PCa, although until now the potential benefits of RARP in comparison to alternative surgical procedures have still not been evaluated in prospective randomized trials. Against the background that also in Germany a continuously and fast growing number of patients are treated by RARP, the present article provides a comprehensive and critical review of internationally published data concerning oncological and functional results of RARP. The main focus represents evaluation of the safety of this procedure with respect to achieving Pentafecta criteria (i.e. no biochemical recurrence, complete urinary continence and erectile function, negative surgical margins, and no postoperative complications), which were primarily described by Patel et al. in 2011.
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Literatur
- 1 Heidenreich A, Bastian PJ, Bellmunt J et al. EAU guidelines on prostate cancer. part 1: screening, diagnosis, and local treatment with curative intent-update 2013. Eur Urol 2014; 65: 124-137
- 2 Binder J, Kramer W. Robotically-assisted laparoscopic radical prostatectomy. BJU Int 2001; 87: 408-410
- 3 Menon M, Shrivastava A, Tewari A et al. Laparoscopic and robot assisted radical prostatectomy: establishment of a structured program and preliminary analysis of outcomes. J Urol 2002; 168: 945-949
- 4 Liss MA, Lusch A, Morales B et al. Robot-assisted radical prostatectomy: 5-year oncological and biochemical outcomes. J Urol 2012; 188: 2205-2210
- 5 Merseburger AS, Herrmann TR, Shariat SF et al. EAU guidelines on robotic and single-site surgery in urology. Eur Urol 2013; 64: 277-291
- 6 Al-Hathal N, El-Hakim A. Perioperative, oncological and functional outcomes of the first robotic prostatectomy program in Quebec: Single fellowship-trained surgeonʼs experience of 250 cases. Can Urol Assoc J 2013; 7: 326-332
- 7 Ko YH, Coelho RF, Chauhan S et al. Factors affecting return of continence 3 months after robot-assisted radical prostatectomy: analysis from a large, prospective data by a single surgeon. J Urol 2012; 187: 190-194
- 8 Sooriakumaran P, Srivastava A, Shariat SF et al. A Multinational, Multi-institutional Study Comparing Positive Surgical Margin Rates Among 22393 Open, Laparoscopic, and Robot-assisted Radical Prostatectomy Patients. Eur Urol 2013; 66: 450-456
- 9 Tewari AK, Ali A, Metgud S et al. Functional outcomes following robotic prostatectomy using athermal, traction free risk-stratified grades of nerve sparing. World J Urol 2013; 31: 471-480
- 10 Moran PS, OʼNeill M, Teljeur C et al. Robot-assisted radical prostatectomy compared with open and laparoscopic approaches: a systematic review and meta-analysis. Int J Urol 2013; 20: 312-321
- 11 Patel VR, Sivaraman A, Coelho RF et al. Pentafecta: a new concept for reporting outcomes of robot-assisted laparoscopic radical prostatectomy. Eur Urol 2011; 59: 702-707
- 12 Robertson C, Close A, Fraser C et al. Relative effectiveness of robot-assisted and standard laparoscopic prostatectomy as alternatives to open radical prostatectomy for treatment of localised prostate cancer: a systematic review and mixed treatment comparison meta-analysis. BJU Int 2013; 112: 798-812
- 13 Montorsi F, Wilson TG, Rosen RC et al. Best practices in robot-assisted radical prostatectomy: recommendations of the Pasadena Consensus Panel. Eur Urol 2012; 62: 368-381
- 14 Siemer S, Stockle M. [Robotic medicine in Germany: quo vadis?]. Urologe A 2011; 50: 928-931
- 15 Ploussard G, Briganti A, de la Taille A et al. Pelvic lymph node dissection during robot-assisted radical prostatectomy: efficacy, limitations, and complications-a systematic review of the literature. Eur Urol 2014; 65: 7-16
- 16 Van Velthoven RF, Ahlering TE, Peltier A et al. Technique for laparoscopic running urethrovesical anastomosis: the single knot method. Urology 2003; 61: 699-702
- 17 White MA, Haber GP, Autorino R et al. Robotic laparoendoscopic single-site radical prostatectomy: technique and early outcomes. Eur Urol 2010; 58: 544-550
- 18 Eggener SE, Scardino PT, Walsh PC et al. Predicting 15-year prostate cancer specific mortality after radical prostatectomy. J Urol 2011; 185: 869-875
- 19 Joslyn SA, Konety BR. Impact of extent of lymphadenectomy on survival after radical prostatectomy for prostate cancer. Urology 2006; 68: 121-125
- 20 Bill-Axelson A, Holmberg L, Garmo H et al. Radical prostatectomy or watchful waiting in early prostate cancer. N Engl J Med 2014; 370: 932-942
- 21 Heidenreich A, Varga Z, Von Knobloch R. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis. J Urol 2002; 167: 1681-1686
- 22 Makarov DV, Trock BJ, Humphreys EB et al. Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000 to 2005. Urology 2007; 69: 1095-1101
- 23 van der Poel HG, de Blok W. Role of extent of fascia preservation and erectile function after robot-assisted laparoscopic prostatectomy. Urology 2009; 73: 816-821
- 24 Freire MP, Choi WW, Lei Y et al. Overcoming the learning curve for robotic-assisted laparoscopic radical prostatectomy. Urol Clin North Am 2010; 37: 37-47 Table
- 25 van den Berg NS, van Leeuwen FW, van der Poel HG. Fluorescence guidance in urologic surgery. Curr Opin Urol 2012; 22: 109-120
- 26 Thompson Jr IM, Tangen CM. Prostate cancer–uncertainty and a way forward. N Engl J Med 2012; 367: 270-271
- 27 Parker C, Muston D, Melia J et al. A model of the natural history of screen-detected prostate cancer, and the effect of radical treatment on overall survival. Br J Cancer 2006; 94: 1361-1368
- 28 Carter HB, Partin AW, Walsh PC et al. Gleason score 6 adenocarcinoma: should it be labeled as cancer?. J Clin Oncol 2012; 30: 4294-4296
- 29 Salomon L, Saint F, Anastasiadis AG et al. Combined reporting of cancer control and functional results of radical prostatectomy. Eur Urol 2003; 44: 656-660
- 30 Bianco Jr FJ, Scardino PT, Eastham JA. Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function („trifecta“). Urology 2005; 66 (Suppl. 05) 83-94
- 31 Ficarra V, Sooriakumaran P, Novara G et al. Systematic review of methods for reporting combined outcomes after radical prostatectomy and proposal of a novel system: the survival, continence, and potency (SCP) classification. Eur Urol 2012; 61: 541-548
- 32 Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004; 240: 205-213
- 33 Schroeck FR, Krupski TL, Stewart SB et al. Pretreatment expectations of patients undergoing robotic assisted laparoscopic or open retropubic radical prostatectomy. J Urol 2012; 187: 894-898
- 34 Wittmann D, He C, Coelho M et al. Patient preoperative expectations of urinary, bowel, hormonal and sexual functioning do not match actual outcomes 1 year after radical prostatectomy. J Urol 2011; 186: 494-499
- 35 Porres D, Pfister D, Labanaris AP et al. [Robot-assisted radical prostatectomy in elderly patients: surgical, oncological and functional outcomes]. Urologe A 2012; 51: 1424-1431
- 36 Bouchier-Hayes DM, Clancy KX, Canavan K et al. Initial consecutive 125 cases of robotic assisted laparoscopic radical prostatectomy performed in Irelandʼs first robotic radical prostatectomy centre. Ir J Med Sci 2012; 181: 21-25
- 37 Carlucci JR, Nabizada-Pace F, Samadi DB. Robot-assisted laparoscopic radical prostatectomy: technique and outcomes of 700 cases. Int J Biomed Sci 2009; 5: 201-208
- 38 Asimakopoulos AD, Miano R, Di Lorenzo N et al. Laparoscopic versus robot-assisted bilateral nerve-sparing radical prostatectomy: comparison of pentafecta rates for a single surgeon. Surg Endosc 2013; 27: 4297-4304
- 39 Patel VR, Abdul-Muhsin HM, Schatloff O et al. Critical review of ‘pentafecta’ outcomes after robot-assisted laparoscopic prostatectomy in high-volume centres. BJU Int 2011; 108: 1007-1017
- 40 Menon M, Bhandari M, Gupta N et al. Biochemical recurrence following robot-assisted radical prostatectomy: analysis of 1384 patients with a median 5-year follow-up. Eur Urol 2010; 58: 838-846
- 41 Thompson JE, Egger S, Bohm M et al. Superior quality of life and improved surgical margins are achievable with robotic radical prostatectomy after a long learning curve: a prospective single-surgeon study of 1552 consecutive cases. Eur Urol 2014; 65: 521-531
- 42 Sooriakumaran P, John M, Wiklund P et al. Learning curve for robotic assisted laparoscopic prostatectomy: a multi-institutional study of 3794 patients. Minerva Urol Nefrol 2011; 63: 191-198