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Klin Padiatr 2013; 225(06): 354-356
DOI: 10.1055/s-0033-1355428
Report
© Georg Thieme Verlag KG Stuttgart · New York

Myeloid and Plasmacytoid Dendritic Cells: Reference Ranges in the Peripheral Blood of Healthy Children

Myeloide und plasmazytoide Dendritische Zellen: Referenzwerte im peripheren Blut gesunder Kinder
O. Ciocarlie
1   Hannover Medical School, IFB-Tx, Institute of Cellular Therapeutics, GMP-DU, Hannover, Germany
4   Pediatrics Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
,
A. Heinze
2   Pediatrics Department, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
,
M. C. Elze
3   Department of Statistics, University of Warwick, Coventry, United Kingdom
,
S. Kloess
1   Hannover Medical School, IFB-Tx, Institute of Cellular Therapeutics, GMP-DU, Hannover, Germany
,
T. Klingebiel
2   Pediatrics Department, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
,
M. Serban
4   Pediatrics Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania
,
U. Koehl
1   Hannover Medical School, IFB-Tx, Institute of Cellular Therapeutics, GMP-DU, Hannover, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
24 October 2013 (online)

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Abstract

To date, few publications report on dendritic cells values in healthy children and mostly are found as control groups in studies focused on either allergic and autoimmune diseases or malignancies. This report provides an overview of 8 publications regarding absolute dendritic cells quantification in the peripheral blood of healthy children by using minimum manipulated samples processed within 24 hours.

Zusammenfassung

Bisher gibt es nur wenige Publikationen über Normwerte Dendritischer Zellen in gesunden Kindern, die zumeist als Werte aus Kontrollgruppen zu Studien über Autoimmunerkrankungen oder maligne Erkrankungen erhoben wurden. Im vorliegenden Report wird daher eine Übersicht über 8 Publikationen zu den Absolutwerten Dendritischer Zellen im peripheren Blut gesunder Kinder präsentiert. Einbezogen wurden Ergebnisse von Proben ohne größere Manipulation, die innerhalb von 24 Stunden gemessen wurden.

Key words

dendritic cells - reference ranges - peripheral blood - healthy children

Schlüsselwörter

Dendritische Zellen - Referenzbereiche - peripheres Blut - gesunde Kinder
 

  • References

  • 1 Ackermann B, Tröger A, Glouchkova L et al. Characterization of CD34+ progenitor-derived dendritic cells pulsed with tumor cell lysate for a vaccination strategy in children with malignant solid tumors and a poor prognosis. Klin Pädiatr 2004; 216: 176-182
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Cseh A, Vasarhelyi B, Molnar K et al. Immune phenotype in children with therapy-naïve remitted and relapsed Crohn’s disease. World J Gastroenterol 2010; 16: 6001-6009
    PubMedGoogle Scholar
  • 3 Feucht J, Joachim L, Lang P et al. Adoptive T-cell transfer for refractory viral infections with cytomegalovirus, Epstein-Barr virus or adenovirus after allogeneic stem cell transplantation. Klin Pädiatr 2013; 225: 164-169
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Hagendorens MM, Ebo DG, Schuerwegh AJ et al. Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children. Clin Exp Allergy 2003; 33: 633-639
    CrossrefPubMedGoogle Scholar
  • 5 Heinze A, Elze MC, Kloess S et al. Age-matched dendritic cell subpopulations reference values in childhood. Scand J Immunol 2013; 77: 213-220
    CrossrefPubMedGoogle Scholar
  • 6 Hönig M, Schulz A, Friedrich W et al. Hematopoietic stem cell transplantation for severe combined immunodeficiency. Klin Pädiatr 2011; 223: 320-325
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Kremser A, Kufner S, Konhaeuser E et al. Combined immunophenotyping and fluorescence in situ hybridization with chromosome-specific DNA probes allows quantification and differentiation of ex vivo generated dendritic cells, leukemia-derived dendritic cells and clonal leukemic cells in patients with acute myeloid leukemia. Leuk & Lymphoma 2013; 54: 1297-1308
    PubMedGoogle Scholar
  • 8 Maecker B, Mougiakakos D, Zimmermann M et al. Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients. Leukemia 2006; 20: 645-649
    PubMedGoogle Scholar
  • 9 Pichyangkul S, Endy TP, Kalayanarooj S et al. A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity. J Immunol 2003; 171: 5571-5578
    PubMedGoogle Scholar
  • 10 Teig N, Moses D, Gieseler S et al. Age-related changes in human blood dendritic cell subpopulations. Scand J Immunol 2002; 55: 453-457
    CrossrefPubMedGoogle Scholar
  • 11 Vakkila J, Thomson AW, Vettenranta K et al. Dendritic cell subsets in childhood and in children with cancer: relation to age and disease prognosis. Clin Exp Immunol 2004; 135: 455-461
    CrossrefPubMedGoogle Scholar
  • 12 Vuckovic S, Gardiner D, Field K et al. Monitoring dendritic cells in clinical practice using a new whole blood single-platform TruCOUNT assay. J Immunol Methods 2004; 284: 73-87
    CrossrefPubMedGoogle Scholar