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Semin Thromb Hemost 2013; 39(06): 674-683
DOI: 10.1055/s-0033-1353394
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Sticky Platelet Syndrome

Peter Kubisz
1   Department of Hematology and Transfusion Medicine, Jessenius Faculty of Medicine of the Comenius University, University Hospital, Martin, Slovakia
,
Jan Stasko
1   Department of Hematology and Transfusion Medicine, Jessenius Faculty of Medicine of the Comenius University, University Hospital, Martin, Slovakia
,
Pavol Holly
1   Department of Hematology and Transfusion Medicine, Jessenius Faculty of Medicine of the Comenius University, University Hospital, Martin, Slovakia
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Publikationsdatum:
10. August 2013 (online)

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Abstract

Sticky platelet syndrome (SPS) is a thrombophilic thrombocytopathy with familial occurrence and autosomal dominant trait, characterized by an increased in vitro platelet aggregation in response to low concentrations of adenosine diphosphate (ADP) and/or epinephrine (EPI). According to aggregation pattern, three types of the syndrome can be identified (hyperresponse after both reagents, Type I; EPI alone, Type II; ADP alone, Type III). Clinically, the syndrome is associated with both venous and arterial thrombosis. In pregnant women, complications such as fetal growth retardation and fetal loss have been reported. The first thrombotic event usually occurs before 40 years of age and without prominent acquired risk factors. Antiplatelet drugs generally represent adequate treatment. The use of other antithrombotics is usually ineffective and may result in the recurrence of thrombosis. In most patients, low doses of antiplatelet drugs (acetylsalicylic acid, 80–100 mg/d) lead to normalization of hyperaggregability. Combination of SPS with other thrombophilic disorders has been described. Despite several studies investigating platelet glycoproteins' role in platelets' activation and aggregation, the precise defect responsible for the syndrome remains unknown. The aim of this review is to summarize authors' own experience about SPS and the clinical data indexed in selected databases of medical literature (PubMed and Scopus).

Keywords

sticky platelet syndrome - platelet hyperaggregability - thrombophilia - platelet disorders
 

  • References

  • 1 Bolton-Maggs PH, Chalmers EA, Collins PW , et al; UKHCDO. A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol 2006; 135 (5) 603-633
    CrossrefPubMedGoogle Scholar
  • 2 Nurden AT, Freson K, Seligsohn U. Inherited platelet disorders. Haemophilia 2012; 18 (Suppl. 04) 154-160
    CrossrefPubMedGoogle Scholar
  • 3 Holiday PL, Mammen E, Gilroy J. Sticky platelet syndrome and cerebral infarction in young adults. Paper presented at: The Ninth International Joint Conference on Stroke and Cerebral Circulation; 1983; Phoenix, AZ, USA
    PubMedGoogle Scholar
  • 4 Sinzinger H, Kaliman J, O'Grady J. Platelet lipoxygenase defect (Wien-Penzing defect) in two patients with myocardial infarction. Am J Hematol 1991; 36 (3) 202-205
    CrossrefPubMedGoogle Scholar
  • 5 Beer JH, Pederiva S, Pontiggia L. Genetics of platelet receptor single-nucleotide polymorphisms: clinical implications in thrombosis. Ann Med 2000; 32 (Suppl. 01) 10-14
    PubMedGoogle Scholar
  • 6 al-Mefty O, Marano G, Raiaraman S, Nugent GR, Rodman N. Transient ischemic attacks due to increased platelet aggregation and adhesiveness. Ultrastructural and functional correlation. J Neurosurg 1979; 50 (4) 449-453
    CrossrefPubMedGoogle Scholar
  • 7 Mammen EF. Ten years' experience with the “Sticky platelet syndrome”. Clin Appl Thromb Hemost 1995; 1: 66-72
    CrossrefPubMedGoogle Scholar
  • 8 Rubenfire M, Blevins RD, Barnhart M, Housholder S, Selik N, Mammen EF. Platelet hyperaggregability in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol 1986; 57 (8) 657-660
    CrossrefPubMedGoogle Scholar
  • 9 Mammen EF, Barnhart MI, Selik NR, Gilroy J, Klepach GL. “Sticky platelet syndrome”: a congenital platelet abnormality predisposing to thrombosis?. Folia Haematol Int Mag Klin Morphol Blutforsch 1988; 115 (3) 361-365
    PubMedGoogle Scholar
  • 10 Mammen EF. Sticky platelet syndrome. Semin Thromb Hemost 1999; 25 (4) 361-365
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 11 Bick RL. Sticky platelet syndrome: A common cause of unexplained arterial and venous thrombosis. Clin Appl Thromb Hemost 1998; 4: 77-81
    CrossrefPubMedGoogle Scholar
  • 12 Warrier I, Nigro M, Hillman C , et al. Platelet activation associated with stroke migraine in children. Thromb Haemost 1991; 65: 772
    PubMedGoogle Scholar
  • 13 Berg-Dammer E, Henkes H, Trobisch H, Kühne D. Sticky platelet syndrome: a cause of neurovascular thrombosis and thromboembolism. Interv Neuroradiol 1997; 3 (2) 145-154
    CrossrefPubMedGoogle Scholar
  • 14 Chittoor SR, Elsehety AE, Roberts GF, Laughlin WR. Sticky platelet syndrome: a case report and review of the literature. Clin Appl Thromb Hemost 1998; 4: 280-284
    CrossrefPubMedGoogle Scholar
  • 15 Andersen JA. Report: bleeding and thrombosis in women. Biomed Progress 1999; 12: 40
    PubMedGoogle Scholar
  • 16 Chaturvedi S, Dzieczkowski JS. Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. Cerebrovasc Dis 1999; 9 (2) 127-130
    CrossrefPubMedGoogle Scholar
  • 17 Ruiz-Argüelles GJ, López-Martínez B, Cruz-Cruz D, Esparza-Silva L, Reyes-Aulis MB. Primary thrombophilia in Mexico III: a prospective study of the sticky platelet syndrome. Clin Appl Thromb Hemost 2002; 8 (3) 273-277
    CrossrefPubMedGoogle Scholar
  • 18 Frenkel EP, Mammen EF. Sticky platelet syndrome and thrombocythemia. Hematol Oncol Clin North Am 2003; 17 (1) 63-83
    CrossrefPubMedGoogle Scholar
  • 19 Lewerenz V, Burchardt T, Büchau A, Ruzicka T, Megahed M. [Livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome]. Hautarzt 2004; 55 (4) 379-381
    CrossrefPubMedGoogle Scholar
  • 20 Ruiz-Argüelles GJ, López-Martínez B, Valdés-Tapia P, Gómez-Rangel JD, Reyes-Núñez V, Garcés-Eisele J. Primary thrombophilia in Mexico. V. A comprehensive prospective study indicates that most cases are multifactorial. Am J Hematol 2005; 78 (1) 21-26
    CrossrefPubMedGoogle Scholar
  • 21 Bick RL, Hoppensteadt D. Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update. Clin Appl Thromb Hemost 2005; 11 (1) 1-13
    CrossrefPubMedGoogle Scholar
  • 22 Kahles H, Trobisch H, Kehren H. [Disseminated coronary occlusions and massive pulmonary embolism in a 40-year-old woman]. Dtsch Med Wochenschr 2006; 131 (13) 672-675
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 23 Fodor M, Facskó A, Berényi E, Sziklai I, Berta A, Pfliegler G. Transient visual loss triggered by scuba diving in a patient with a petrous epidermoid and combined thrombotic risk factors. Pathophysiol Haemost Thromb 2007; 36 (6) 311-314
    CrossrefPubMedGoogle Scholar
  • 24 Randhawa S, Van Stavern GP. Sticky platelet syndrome and anterior ischaemic optic neuropathy. Clin Experiment Ophthalmol 2007; 35 (8) 779-781
    CrossrefPubMedGoogle Scholar
  • 25 Mühlfeld AS, Ketteler M, Schwamborn K , et al. Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients. Am J Transplant 2007; 7 (7) 1865-1868
    CrossrefPubMedGoogle Scholar
  • 26 El-Amm JM, Andersen J, Gruber SA. Sticky platelet syndrome: a manageable risk factor for posttransplant thromboembolic events. Am J Transplant 2008; 8 (2) 465
    CrossrefPubMedGoogle Scholar
  • 27 Kannan S. Recurrent arterial thrombosis in a young male: sticky platelet syndrome. Internet J Hematol 2008; 4(1) :DOI 10.5580/d76
    PubMedGoogle Scholar
  • 28 Sand M, Mann B, Bechara FG, Sand D. Sticky platelet syndrome type II presenting with arterial microemboli in the fingers. Thromb Res 2009; 124 (2) 244
    CrossrefPubMedGoogle Scholar
  • 29 Mears KA, Van Stavern GP. Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome. Br J Ophthalmol 2009; 93 (7) 885-886 , 913
    CrossrefPubMedGoogle Scholar
  • 30 Bojalian MO, Akingba AG, Andersen JC , et al. Sticky platelet syndrome: an unusual presentation of arterial ischemia. Ann Vasc Surg 2010; 24 (5) e1-e6
    CrossrefPubMedGoogle Scholar
  • 31 Loeffelbein DJ, Baumann CM, Mücke T, Wolff KD, Hölzle F, Kesting MR. Sticky platelet syndrome as a possible cause for free flap failure—a case report. Microsurgery 2010; 30 (6) 466-468
    CrossrefPubMedGoogle Scholar
  • 32 Rac MW, Minns Crawford N, Worley KC. Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome. Obstet Gynecol 2011; 117 (2 Pt 2) 501-503
    CrossrefPubMedGoogle Scholar
  • 33 Gehoff A, Kluge JG, Gehoff P , et al. Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale. J Cardiovasc Dis Res 2011; 2 (1) 68-70
    CrossrefPubMedGoogle Scholar
  • 34 Guillermo J, Ruiz-Argüelles GJ, Alarcón-Urdaneta C, Calderón-García J, Ruiz-Delgado GJ. Primary thrombophilia in México VIII: Description of five kindreds of familial sticky platelet syndrome phenotype. Rev Hematol Mex 2011; 12: 73-78
    PubMedGoogle Scholar
  • 35 Simonová R, Bartosová L, Chudý P , et al. Nine kindreds of familial sticky platelet syndrome phenotype. Clin Appl Thromb Hemost 2013; 19 (4) 395-401
    CrossrefPubMedGoogle Scholar
  • 36 Kubisz P, Ivankov J, Hollý P, Staško JN, Musiał J. The glycoprotein IIIa PL(A1/A2) polymorphism—a defect responsible for the sticky platelet syndrome?. Clin Appl Thromb Hemost 2006; 12 (1) 117-119
    CrossrefPubMedGoogle Scholar
  • 37 Kubisz P, Bartosová L, Ivanková J , et al. Is Gas6 protein associated with sticky platelet syndrome?. Clin Appl Thromb Hemost 2010; 16 (6) 701-704
    CrossrefPubMedGoogle Scholar
  • 38 Staško J, Bartošová L, Mýtnik M, Kubisz P. Are the platelets activated in sticky platelet syndrome?. Thromb Res 2011; 128 (1) 96-97
    CrossrefPubMedGoogle Scholar
  • 39 Ruiz-Argüelles GJ, Garcés-Eisele J, Camacho-Alarcón C , et al. Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. Clin Appl Thromb Hemost 2012; ; Epub ahead of print
    PubMedGoogle Scholar
  • 40 Kubisz P, Ivanková J, Škereňová M, Staško J, Hollý P. The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. Hematology 2012; 17 (6) 355-362
    CrossrefPubMedGoogle Scholar
  • 41 Sokol J, Biringer K, Škereňová M , et al. Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism. Fertil Steril 2012; 98 (5) 1170-1174
    CrossrefPubMedGoogle Scholar
  • 42 Kotuličová D, Chudý P, Škereňová M, Ivanková J, Dobrotová M, Kubisz P. Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. Blood Coagul Fibrinolysis 2012; 23 (6) 543-547
    CrossrefPubMedGoogle Scholar
  • 43 Clemetson KJ, Clemetson JM. Platelet receptors. In: Michelson AD, , ed. Platelets. Second Edition. Oxford, UK: Elsevier Inc.; 2007: 117-144
    CrossrefGoogle Scholar
  • 44 Feng D, Lindpaintner K, Larson MG , et al. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1999; 19 (4) 1142-1147
    CrossrefPubMedGoogle Scholar
  • 45 Muñoz X, Obach V, Hurtado B, de Frutos PG, Chamorro A, Sala N. Association of specific haplotypes of GAS6 gene with stroke. Thromb Haemost 2007; 98 (2) 406-412
    PubMedGoogle Scholar
  • 46 Cole VJ, Staton JM, Eikelboom JW , et al. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. J Thromb Haemost 2003; 1 (5) 963-970
    CrossrefPubMedGoogle Scholar
  • 47 Ollikainen E, Mikkelsson J, Perola M, Penttilä A, Karhunen PJ. Platelet membrane collagen receptor glycoprotein VI polymorphism is associated with coronary thrombosis and fatal myocardial infarction in middle-aged men. Atherosclerosis 2004; 176 (1) 95-99
    CrossrefPubMedGoogle Scholar
  • 48 Shaffer JR, Kammerer CM, Dorn J , et al. Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. Nutr Metab Cardiovasc Dis 2011; 21 (8) 546-552
    CrossrefPubMedGoogle Scholar
  • 49 Johnson AD, Yanek LR, Chen MH , et al. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 2010; 42 (7) 608-613
    CrossrefPubMedGoogle Scholar
  • 50 Ferreiro JL, Gómez-Hospital JA, Angiolillo DJ. Platelet abnormalities in diabetes mellitus. Diab Vasc Dis Res 2010; 7 (4) 251-259
    CrossrefPubMedGoogle Scholar
  • 51 Bergmeier W, Wagner DD. Inflammation. In: Michelson AD, , ed. Platelets. Second Edition. Oxford, UK: Elsevier Inc.; 2007: 117-144
    Google Scholar