Planta Med 2013; 79 - PJ47
DOI: 10.1055/s-0033-1352251

Chemical composition and biological activities of extracts from an endemic Salvia cilicica Boiss.

N Tan 1, B Sen 1, F Onat 2, N Carcak 3, E Specker 4, E Tan 5
  • 1University of Istanbul, Faculty of Pharmacy, Department of Pharmacognosy, 34116, Istanbul, Turkey
  • 2University of Marmara, School of Medicine, Department of Pharmacology, 1883, Istanbul, Turkey
  • 3University of Istanbul, Faculty of Pharmacy, Department of Pharmacology, 34116, Istanbul, Turkey
  • 4Screening Unit, Leibniz Institute of Molecular Pharmacology FMP, Campus Berlin-Buch, Robert-Roessle Str. 10, 13125 Berlin, Germany
  • 5University of Yeni Yüzyıl, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 34010, Istanbul, Türkiye

The genus Salvia L. (Lamiaceae) comprises about 900 species around the world, while it is presented with 89 species and 93 taxons in Turkey, approximately half of which is endemic (1,2). Anatolia is the major gene center in Asia. The previous studies on this genus were about the isolation of their terpenic and flavonoid compounds and some biological activities. An endemic species in Adana-Pozanti, Salvia cilicica, has only a limited number of studies in the literature regarding its chemical composition and biological activity.

In our previous study, we presented the isolation of the terpenic compounds and the antileishmanial, antioxidant and cytotoxic activities of S. cilicica, which is endemic and is utilized in traditional medicine (3, 4). Because the successful study results of the biological activities of S. cilicica, further studies on the species other possible usages shall be conducted.

The present study concentrated on the compounds isolation and structure identifications (using spectroscopic methods 1H NMR, 13C NMR, HETCOR, COSY, NOESY, HSQC, HMBC, UV, IR, Mass) from the aerial parts and to determine the antimicrobial activity and preliminary studies on antiepileptic activity of the various extracts from the aerial parts and roots of S. cilicica.

Keywords: Salvia cilicica, isolation, antimicrobial activity, antiepileptic activity

References:

[1] Davis P.H. (Ed.). Flora of Turkey and the East Aegean Islands. Vol VII. Edinburgh: Edinburgh University Press, 1988.

[2] Davis P.H. (Ed.). Flora of Turkey and the East Aegean Islands. Vol X. Edinburgh: Edinburgh University Press, 1988.

[3] Tan N. et al. Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities. Phytochemistry. 2002; 61: 881 – 884.

[4] Şen B., Yılmaz Özden T., Meriçli F., Meriçli A.H., Tan N., “Toros Dağları'nın Endemik Değeri Salvia cilicica Bitkisinin Aktivite Açısından Değerlendirilmesi”, XX.BİHAT 10 – 13 September 2012, Antalya – Turkey