Planta Med 2013; 79 - PI93
DOI: 10.1055/s-0033-1352182

New neolignans from leaves of Miliusa mollis

K Sawasdee 1, T Chaowasku 2, V Lipipun 3, T Dufat 4, S Michel 4, K Likhitwitayawuid 1
  • 1Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
  • 2Nationaal Herbarium Nederland, Leiden University, The Netherlands
  • 3Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
  • 4Département de Physico-chimie du medicament, Faculté des sciences pharmaceutiques et biologiques, Université Paris Descartes, Paris 75006, France

Miliusa mollis Pierre (Annonaceae) is a shrub found in the northern and central regions of Thailand where it is locally known as Ching-chap [1]. Recently, the presence of neolignans, aporphine alkaloids and phenolic glycoside in the twigs of M. mollis has been reported [2]. In this study, we report the isolation of six new neolignans from the leaves of this plant including miliumollin (1), 4'-O-methylmiliumollin (2), 3'-methoxymiliumollin (3), 7-methoxymiliumollin (4), miliumollinone (5) and miliusamollin (6), and a known compound named decurrenal (7). Their structures were elucidated through analysis of their spectroscopic data. Four neolignans (1, 3, 5 and 7) exhibited weak cytotoxic against KB, MCF7 and NCI-H187 cells, but only 5 showed weak inhibitory effects against herpes simplex virus types 1 and 2 (HSV1 and HSV-2).

Fig. 1

Acknowledgements: The Thailand Research Found in the form of a Royal Golden Jubilee Ph.D. scholarship (PHD/0261/2549), The French Embassy in Thailand for an RGJ-matching grant, Chulalongkorn University Graduate Scholaship in Commemoration of HM King Bhumibol Adulyadej's 72nd Anniversary

References:

[1] Smitinand, T. (2001) Thai Plant Names, revised Ed. Prachachon Co. Ltd. Bangkok, Thailand.

[2] Sawasdee, K. et al. (2010) Molecules 15: 639 – 648.