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DOI: 10.1055/s-0033-1352143
New secondary metabolites from Gentiana spec.
The genus Gentiana (Gentianaceae) consists of many species with interesting phytochemical properties which have been widely used in traditional folk medicine [1]. Some members of Gentiana are used as folk remedies in Anatolia for their antipyretic, stomachic, stimulant of appetite, hepatoprotective, antidepressant and antidiabetic activities [2 – 5]. Iridoids, secoiridoids, C-glycosylflavones and xanthones are considered as the most promising groups of compounds responsible for the pharmacological activities of Gentiana species [1]. In a continuation of the phytochemical investigations on the genus, we have isolated one new flavonoid C-glucoside (1) along with 4 known compounds (2 – 5) from Gentiana pyrenaica and one new secoiridoid glucoside (6) and a known xanthone (7) from Gentiana verna subsp. pontica. The compounds were characterized by various chromatographic methods and the structures of the isolates were elucidated by means of spectroscopic (1H-NMR, 13C-NMR, 2D-NMR and Mass spectr.) evidence.
Acknowledgement: This work was supported by Hacettepe University Research Foundation (Project No. 0601301004).
References:
[1] Jensen S.R., Schripsema J. (2002) GENTIANACEA-Systematics and Natural History, Struwe, L., Albert, V. Eds., Cambridge University Press.
[2] Baytop, T. (1999) Therapy with Medicinal Plants in Turkey (Past and Present), 2nd edn. Nobel Publication, İstanbul.
[3] Ersöz, T., et al. (1991) Fitoterapia 62: 184 – 185.
[4] Sezik, E., et al. (2005) Life Sci. 76: 1223 – 1238.
[5] Deliorman, O.D., et al. (2003) Life Sci. 72: 2273 – 2283.