Planta Med 2013; 79 - PI37
DOI: 10.1055/s-0033-1352127

Secondary metabolites of Plantago lagopus L.

Y Genç 1, I Saracoglu 1, A Nagatsu 2, S Harput 1
  • 1Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy,06100, Sihhiye, Ankara
  • 2Kinjo Gakuin University, College of Pharmacy, Ohmori, Nagoya, Japan

The genus Plantago (Plantaginaceae) is represented by 21 species in Turkey (1). Up to now, several effects have been described for the genus Plantago such as antitumoral, antiinflammatory, antibacterial, analgesic and hepatoprotective (2,3). Earlier investigations about Plantago species resulted in the isolation of mainly iridoid, phenylethanoid and flavonoid glycosides; polysaccharides and lipids (4). In this study; as a result of bioactivity guided isolation method, acteoside and calceorioside A were isolated from the most active fraction and they showed strong radical scavenging effect against DPPH, NO and SO radicals and cytotoxic activity against HEP-2, RD and MCF-7 cancer cell lines. In addition; aucubin, catalpol, rehmaglutine D and phlomuroside were obtained from the inactive fractions. Isolation of rehmaglutine D and phlomuroside from P. lagopus is important for the chemotaxonomic view of the genus. This is the first report for the bioactivity guided isolation of acteoside and calceorioside A from P. lagopus. This study was supported by the project of TUBITAK (108T518).

References:

[1] Davis, P.H. Flora of Turkey and the East Aegean Islands (1982).

[2] Baytop, T. Therapy with Medicinal Plants in Turkey (Past and Present) (1999).

[3] Stanisavljevic, I.T., et al., Separation Science and Technology (2008).

[4] Samuelsen, A.B., Journal of Ethnopharmacology (2000).