Planta Med 2013; 79 - PI25
DOI: 10.1055/s-0033-1352115

A new resveratrol derivative, 4a,4b-O-dimethyl-ε-viniferin from Vitis thunbergii var. thunbergii

JJ Chen 1, YM Huang 1, TL Hwang 2, SR Chen 1, YJ Liang 1
  • 1Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
  • 2Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

Vitis thunbergii Sieb. & Zucc. var. thunbergii (Vitaceae) is a liana (vine), distributed in China, Japan, Korea, and Taiwan. It has been used as a traditional medicine for diarrhea, fracture, injury, jaundice, and hepatitis in Taiwan. Various oligostilbenes, resveratrols, and their derivatives are widely distributed in plants of genus Vitis. In our studies on the anti-inflammatory constituents of Formosan plants and Chinese herbs, many species have been screened for in vitro anti-inflammatory activity, and V. thunbergii has been found to be an active species. Investigation on EtOAc-soluble fraction of root of V. thunbergii var. thunbergii has led to the isolation of a new resveratrol derivative, 4a,4b-O-dimethyl-ε-viniferin (1), along with 9 known compounds. The structure of new compound 1 was determined through spectroscopic and MS analyses.

Acknowledgement: This research was supported by grants from the National Science Council (NSC, Taiwan) (No. NSC 98 – 2320-B-127 – 001-MY3 and NSC 101 – 2320-B-127 – 001-MY3), awarded to Prof. J.-J. Chen.