Planta Med 2013; 79 - PI21
DOI: 10.1055/s-0033-1352111

Garcimultiflorone G, a novel benzoylphloroglucinol derivative from Garcinia multiflora

JJ Chen 1, CW Ting 2, MH Yen 2, IS Chen 2, TL Hwang 3
  • 1Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
  • 2Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
  • 3Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

Garcinia multiflora (Guttiferae) Champ. is a small evergreen tree, distributed in South China, Hong Kong, and Taiwan. Xanthones, biflavonoids, benzophenones, phloroglucinol, and their derivatives are widely distributed in plants of genus Garcinia. Many of these compounds exhibit anti-inflammatory, anti-HIV, antitubercular, cytotoxic, and antioxidant activities. In our studies on the anti-inflammatory constituents of Formosan plants, many species have been screened for in vitro anti-inflammatory activity, and G. multiflora has been found to be an active species. In our search for compounds with anti-inflammatory activities, an additonal new benzophenone derivative, garcimultiflorone G (1) has been isolated and identified from the fruits of G. multiflora. The structural elucidation of garcimultiflorone G (1) was established by spectroscopic and MS analyses and its anti-inflammatory activity was evaluated by suppressing fMet-Leu-Phe/cytochalasin B (fMLP/CB)-induced superoxide anion (O2 ·-) generation and elastase release by human neutrophils.

Fig. 1

Acknowledgement: This research was supported by grants from the National Science Council (NSC, Taiwan) (No. NSC 98 – 2320-B-127 – 001-MY3 and NSC 101 – 2320-B-127 – 001-MY3), awarded to Prof. J.-J. Chen.